DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh5a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_074042.1	Gene:	Aldh5a1 / 291133	RGDID:	621422	Length:	523	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	132/471 - (28%)
Similarity:	230/471 - (48%)	Gaps:	23/471 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GQWQGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDEL 119
            |:|.....:...|||.:|..:..|....|.|....:..|.:|:..|:::....|..::|:..|.:
  Rat    55 GRWLPTPATFPVYDPASGAKLGTVADCGVPEARAAVRAAYDAFSSWKEISVKERSSLLRKWYDLM 119

  Fly   120 RKYKEPLGKLVSLEVGKIYSEGQGEV---QEFIDICDYAVGLSRIYSGQLINSERADHSILEAWR 181
            .:.|:.|.|:::.|.||...|.|||:   ..|::.  ::....|:| |.:|.:...|...|...:
  Rat   120 IQNKDELAKIITAESGKPLKEAQGEILYSAFFLEW--FSEEARRVY-GDIIYTSAKDKRGLVLKQ 181

  Fly   182 PLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP--- 243
            |:||..:|:.:|||:|:.......||..|.:|:.|.|..||..::|    :|::..:..:||
  Rat   182 PVGVASIITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPYSALA----LAQLANQAGIPPGVY 242

  Fly   244 VVTLCQ--GGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESA 306
            .|..|.  ...:||:.|..|..|:.:|||||..||:.:.........:|.:||||....|:.:||
  Rat   243 NVIPCSRTKAKEVGEVLCTDPLVSKISFTGSTATGKILLHHAANSVKRVSMELGGLAPFIVFDSA 307

  Fly   307 NVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPV 371
            ||..|:..|:......:||.|..:.|.:|...:||.||.:.....|:.: ::|:..|..|..||:
  Rat   308 NVDQAVAGAMASKFRNAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSL-RVGNGFEEGTTQGPL 371

  Fly   372 HTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILK 436
            ..::.||..:..:.:|.:.|.||..||...|..|.:.|||:::.:..|...:..|||.|:..::|
  Rat   372 INEKAVEKVEKHVNDAVAKGATVVTGGKRHQSGGNFFEPTLLSNVTRDMLCITEETFGPLAPVIK 436

  Fly   437 AKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNG--AEIGGAFGGEK 499
            ....::|:...|..:.||:...::::..|.  |..|:..:.|:|.:|   .|  :.:...|||.|
  Rat   437 FDKEEEAVAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVN---EGLISSVECPFGGVK 496

  Fly   500 ATGGGRESGSDAWKQY 515
            .:|.|||.......:|
  Rat   497 QSGLGREGSKYGIDEY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	132/471 (28%)
Aldh5a1	NP_074042.1	SSADH	66..516	CDD:188167	130/460 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810