DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh7A1 and Aldh1a7

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036051.1	Gene:	Aldh1a7 / 26358	MGIID:	1347050	Length:	501	Species:	Mus musculus

Alignment Length:	491	Identity:	138/491 - (28%)
Similarity:	232/491 - (47%)	Gaps:	37/491 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SGQWQGRGPSVTS-----YDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGE 110
            :.:|.   .||:|     .:|.|.:.|..|.:|:..:::..:..|.:|::   .||.:.|..||.
Mouse    26 NNEWH---DSVSSKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGR 87

  Fly   111 IVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQ-GEVQEFIDICDYAVGLSRIYSGQLINSERADH 174
            ::.::.|.:.:.:..|..:.|:..||:::... .:|:..|....|..|.:....||.|.|   |.
Mouse    88 LLNKLADLMERDRLLLATMESMNAGKVFAHAYLLDVEISIKALQYFAGWADKIHGQTIPS---DG 149

  Fly   175 SILEAWR--PLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLR 237
            :|....|  |:||.|.|..:|.|..:|.|....||:.||:|:.|.|..|||    |...:|.:::
Mouse   150 NIFTYTRREPIGVCGQIIPWNGPLIIFTWKLGPALSCGNTVVVKPAEQTPL----TALHMASLIK 210

  Fly   238 RNNLPP-VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGK-----VILELG 295
            ....|| ||.:..| |...|..:.:...::.||||||    .:||..::...||     |.||||
Mouse   211 EAGFPPGVVNIVPGYGPTAGGAISSHMDIDKVSFTGS----TEVGKLIKEAAGKSNLKRVTLELG 271

  Fly   296 GNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGH 360
            |.:..|:...|::..|::.|..|.....||.|....|:.|.|.::|:||:..|.:.|:.|  :|:
Mouse   272 GKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYI--LGN 334

  Fly   361 QLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHR 425
            .|.:....||...::........|...|..|..:..||......||:|:|||.:.:..:..:...
Mouse   335 PLNSGINQGPQIDKEQHNKILGLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKE 399

  Fly   426 ETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAE 490
            |.|.|:..|:|.|::|..|:..|....||::.:||:::.:|.....|  ...|:|.:|... ...
Mouse   400 EIFGPVQQIMKFKSMDDVIKRANNTTYGLAAGVFTKDLDKAITVSSA--LQAGMVWVNCYL-AVP 461

  Fly   491 IGGAFGGEKATGGGRESGSDAWKQYCKRATITVNHS 526
            :...|||.|.:|.|||.|.....:|.:..|:.:..|
Mouse   462 VQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMQIS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	137/489 (28%)
Aldh1a7	NP_036051.1	ALDH_F1AB_F2_RALDH1	15..494	CDD:143459	137/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810