DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh3a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_114178.1	Gene:	Aldh3a1 / 25375	RGDID:	2088	Length:	453	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	117/460 - (25%)
Similarity:	194/460 - (42%)	Gaps:	69/460 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIG-DELRKYKEPLGKLVSLEVGKIYSEGQG 143
            |..:|:||....:..|..|.       :.|.:...:| :|...|.|        ||..:..|...
  Rat    24 QFRIQQLEALQRMINENLKS-------ISGALASDLGKNEWTSYYE--------EVAHVLEELDT 73

  Fly   144 EVQEFIDIC-DYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAI-- 205
            .::|..|.. |..|..:|    |....:...||     .|||||.||.|:|:|     :|..|
  Rat    74 TIKELPDWAEDEPVAKTR----QTQQDDLYIHS-----EPLGVVLVIGAWNYP-----FNLTIQP 124

  Fly   206 ---ALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRR---NNLPPVVTLCQGGTDVGQTLVADKRV 264
               |:..||:|:.|  ||.  ||.....::|.::.:   .||..||   :||......|:.: |.
  Rat   125 MVGAVAAGNAVILK--PSE--VSGHMADLLATLIPQYMDQNLYLVV---KGGVPETTELLKE-RF 181

  Fly   265 NLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTT 329
            :.:.:|||...|:.|.....:....|.|||||.:...:|:..::.:|.....:|....|||.|..
  Rat   182 DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVA 246

  Fly   330 TRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTV 394
            ...|:....:.:|.|::|   .|.|....|...:.....|.:...::.:..|..|...|     |
  Rat   247 PDYILCDPSIQNQIVEKL---KKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK-----V 303

  Fly   395 AFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIF 459
            |.||...| ...|:.||::..:...:.|:..|.|.|::.|:..:::::||::.|:.|:.|:..:|
  Rat   304 AHGGTWDQ-SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367

  Fly   460 TENIGQAFKWI------GAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQYCKR 518
            :.|.....|.|      |...:|. ||:|...|.      .|||...:|.|...|..:::.:..|
  Rat   368 SNNEKVIKKMIAETSSGGVTANDV-IVHITVPTL------PFGGVGNSGMGAYHGKKSFETFSHR 425

  Fly   519 ATITV 523
            .:..|
  Rat   426 RSCLV 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	117/460 (25%)
Aldh3a1	NP_114178.1	ALDH_F3AB	5..447	CDD:143450	117/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900