DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh1a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_038949786.1	Gene:	Aldh1a1 / 24188	RGDID:	2087	Length:	520	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	135/487 - (27%)
Similarity:	230/487 - (47%)	Gaps:	29/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SGQWQG--RGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVR 113
            :.:|..  .|......:|.|.:.|..|.:|:..:::..:..|.:|::   .||.:.|..||.::.
  Rat    45 NNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLN 109

  Fly   114 QIGDELRKYKEPLGKLVSLEVGKIYSEGQ-GEVQEFIDICDYAVGLSRIYSGQLINSERADHSIL 177
            ::.|.:.:.:..|..:.::..||:::... .::...|....|..|.:....||.|.|: .|....
  Rat   110 KLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSD-GDIFTF 173

  Fly   178 EAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLP 242
            ....|:||.|.|..:|||..:|.|....||:.||:|:.|.|..|||    |...:|.:::....|
  Rat   174 TRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPL----TALHMASLIKEAGFP 234

  Fly   243 P-VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGK-----VILELGGNNAL 300
            | ||.:..| |...|..:.:...|:.|:||||.|    ||..::...||     |.|||||.:..
  Rat   235 PGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQ----VGKLIKEAAGKSNLKRVTLELGGKSPC 295

  Fly   301 IIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQ 365
            |:...|::.:|::.|..|.....||.|....||.|.|.::|:||::.|.:.|:.:  :|:.|...
  Rat   296 IVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYV--LGNPLTQG 358

  Fly   366 TLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAP 430
            ...||...::..:.....|...|..|..:..||......||:|:|||.:.:..:..:...|.|.|
  Rat   359 INQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGP 423

  Fly   431 IVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINT-TTNGAEIGGA 494
            :..|:|.|::|..|:..|....||::.:||:::.:|.....|  ...|:|.:|. ....|:.  .
  Rat   424 VQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSA--LQAGVVWVNCYMILSAQC--P 484

  Fly   495 FGGEKATGGGRESGSDAWKQYCKRATITVNHS 526
            |||.|.:|.|||.|.....:|.:..|:.:..|
  Rat   485 FGGFKMSGNGRELGEHGLYEYTELKTVAMKIS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	134/485 (28%)
Aldh1a1	XP_038949786.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	134/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810