DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH9A1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_000687.3	Gene:	ALDH9A1 / 223	HGNCID:	412	Length:	518	Species:	Homo sapiens

Alignment Length:	519	Identity:	145/519 - (27%)
Similarity:	244/519 - (47%)	Gaps:	30/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LPRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYDPGTGQPIAK 77
            |.|.|.....:..|:.::::.||    |...|..|..|...||       :..:::|.||:.||.
Human    13 LLRSLRPSPVAAMSTGTFVVSQP----LNYRGGARVEPADASG-------TEKAFEPATGRVIAT 66

  Fly    78 VRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQ 142
            ......:|:...:..|..|:|.|.|.....|..|:.:....:|:.::.:..:..:..||...|.:
Human    67 FTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR 131

  Fly   143 GEVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAIAL 207
            .::.......:|..||:...:|:.|............ .||||...|.|:|:|..:..|.:|.||
Human   132 LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRR-EPLGVCVGIGAWNYPFQIASWKSAPAL 195

  Fly   208 TTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQGGTDVGQTLVADKRVNLVSFTG 271
            ..||::::|.:|.||:.::    ::||:.....:|| :..:.|||...||.|.....|..|||||
Human   196 ACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTG 256

  Fly   272 SCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVH 336
            |..||..:.....:....|.|||||.:.|||....::..|:..||.....|.||.|....|:.|.
Human   257 SVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQ 321

  Fly   337 EKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVI 401
            :::.|:|.:|:|.:.:::  |||..|...|.:||:..:.::|.....:..||..|..|..||::.
Human   322 KEILDKFTEEVVKQTQRI--KIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 384

  Fly   402 ------QRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFT 460
                  .:||:|:.|.|:|....|.:.|..|.|.|::.||......:.:|..|:...||::.:||
Human   385 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 449

  Fly   461 ENIGQAFKWIG-AKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQYCKRATITV 523
            .:|.:|.:.:. .:...|.|.|.|.:.  .|:  .|||.|.:|.|||:|....:.|.:..|:.|
Human   450 RDIQRAHRVVAELQAGTCFINNYNVSP--VEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	135/481 (28%)
ALDH9A1	NP_000687.3	ALDH_F9_TMBADH	55..512	CDD:143409	133/466 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810