DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH1A3

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_000684.2	Gene:	ALDH1A3 / 220	HGNCID:	409	Length:	512	Species:	Homo sapiens

Alignment Length:	485	Identity:	138/485 - (28%)
Similarity:	241/485 - (49%)	Gaps:	31/485 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SGQW--QGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQ---WRQVPAPVRGEIVR 113
            :.:|  ...|....:.:|.|.:.|.:|.:|:..:::..:..|..|:::   ||::.|..||.::.
Human    37 NNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLH 101

  Fly   114 QIGDELRKYKEPLGKLVSLEVGKIYSEGQGEVQEFIDI--C----DYAVGLSRIYSGQLINSERA 172
            |:.|.:.:.:..|..|.:::.||.:...     .|||:  |    .|..|.:....|:.|.::
Human   102 QLADLVERDRATLAALETMDTGKPFLHA-----FFIDLEGCIRTLRYFAGWADKIQGKTIPTD-- 159

  Fly   173 DHSI-LEAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVL 236
            |:.: .....|:||.|.|:.:|||..:..|..|.||..||:::.|.|..|||    |...:..::
Human   160 DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPL----TALYLGSLI 220

  Fly   237 RRNNLPP-VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQR-RFGKVILELGGNN 298
            :....|| ||.:..| |..||..:.:..::|.::||||.:.|:.|.....| ...:|.|||||.|
Human   221 KEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKN 285

  Fly   299 ALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLE 363
            ..|:...|::.:|::.|..|.....||.||...|:.|.|:::.:||:..|...|:  ..:|...:
Human   286 PCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKK--RPVGDPFD 348

  Fly   364 AQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETF 428
            .:|..||...|:..:.....|...|..|..:..||:.::..|.:::|||.:.:..:..:...|.|
Human   349 VKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIF 413

  Fly   429 APIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGG 493
            .|:..|||.|::::.|:..|..:.||::|:||:|:.:|.|.  |...:.|.|.|| ..|......
Human   414 GPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKL--ASALESGTVWIN-CYNALYAQA 475

  Fly   494 AFGGEKATGGGRESGSDAWKQYCKRATITV 523
            .|||.|.:|.|||.|..|..:|.:..|:|:
Human   476 PFGGFKMSGNGRELGEYALAEYTEVKTVTI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	138/485 (28%)
ALDH1A3	NP_000684.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
ALDH1A3	NP_000684.2	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	138/485 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810