DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_705771.2	Gene:	Aldh1l2 / 216188	MGIID:	2444680	Length:	923	Species:	Mus musculus

Alignment Length:	489	Identity:	142/489 - (29%)
Similarity:	240/489 - (49%)	Gaps:	46/489 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK--QWRQVPAPVRGEIVRQIGDELRKYK 123
            |.:..:.:|..|..|.:|...::.:::..:..|.:|::  :|.::.|..||.::.::.|.:.:.:
Mouse   457 GETYATVNPTDGTTICRVSYASLADVDRAVAAAKDAFENGEWGRMNARDRGRLMYRLADLMEENQ 521

  Fly   124 EPLGKLVSLEVGKIYSEGQG-----EVQE---FIDICDYAVGLSRIYSGQLINSERADHSI-LEA 179
            |.|..:.:|:.|.:|:....     .||.   |...||...|     |...||..|.:::: ...
Mouse   522 EELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQG-----STIPINQARPNYNLTFTK 581

  Fly   180 WRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP- 243
            ..|||...:|..:|:|..:..|.:|..|..||:::.|.|..|||.::.    .||:..:...|.
Mouse   582 KEPLGACAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALK----FAELTVKAGFPKG 642

  Fly   244 VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVE-VQRRFGKVILELGGNNALII---- 302
            |:.:..| |...||.|.....:..:.||||...|:.:... ......||.|||||.:.|||
Mouse   643 VINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVSNLKKVSLELGGKSPLIIFSDC 707

  Fly   303 DESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTL 367
            |....|:|.:.|..|    ..|:.|....|:.|.|.:||:||..:|.:.|::  |||..|:..|.
Mouse   708 DLEKAVRMGMGAVFF----NKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKM--KIGDPLDRSTD 766

  Fly   368 VGP----VHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETF 428
            .||    .|.::.::..:..:.|    |.|:.:||..:||.||::||||.||:.....:...|:|
Mouse   767 HGPQNHRAHLEKLLQYCETGVQE----GATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESF 827

  Fly   429 APIVYILKAKN--VDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEI 491
            .||:.|.|.:|  :|..::..|..|.||:|.:||.:|.:|. ::..| .:.|.|.|| |.|..::
Mouse   828 GPIMVISKFQNGDIDGVLQRANNTEYGLASGVFTRDINKAM-YVSDK-LEAGTVFIN-TYNKTDV 889

  Fly   492 GGAFGGEKATGGGRESGSDAWKQYCKRATITVNH 525
            ...|||.|.:|.|::.|.:|..:|.|..|:|:.:
Mouse   890 AAPFGGMKQSGFGKDLGEEALNEYLKIKTVTLEY 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	142/489 (29%)
Aldh1l2	NP_705771.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..410	CDD:278949
		ALDH_F1L_FTFDH	438..923	CDD:143458	142/487 (29%)
		Aldehyde dehydrogenase	438..923		142/487 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810