DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh5a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_766120.1	Gene:	Aldh5a1 / 214579	MGIID:	2441982	Length:	523	Species:	Mus musculus

Alignment Length:	515	Identity:	142/515 - (27%)
Similarity:	239/515 - (46%)	Gaps:	46/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERD---NPGVYSGQWQGRGPSVTSYDPGTGQPI 75
            |||      ||:|...              ||..|   ......|:|.....:...|||.:|..:
Mouse    31 PRR------SYASGPG--------------GLHADLLRGDSFVGGRWLPAPATFPVYDPASGAKL 75

  Fly    76 AKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSE 140
            ..|....|.|....:..|.:|:..|:.|....|..::|:..|.:.:.|:.|.|:::.|.||...|
Mouse    76 GTVADCGVPEARAAVRAAYDAFNSWKGVSVKERSLLLRKWYDLMIQNKDDLAKIITAESGKPLKE 140

  Fly   141 GQGEV---QEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWN 202
            .|||:   ..|::.  ::....||| |.:|.:...|...|...:|:||..:|:.:|||:|:....
Mouse   141 AQGEILYSALFLEW--FSEEARRIY-GDIIYTSAKDKRGLVLKQPVGVAAIITPWNFPSAMITRK 202

  Fly   203 AAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP----VVTLCQG-GTDVGQTLVADK 262
            ...||..|.:|:.|.|..||..::|    :|::..:..:|.    |:...:. ..:||:.|..|.
Mouse   203 VGAALAAGCTVVVKPAEDTPYSALA----LAQLANQAGIPAGVYNVIPCSRNKAKEVGEVLCTDP 263

  Fly   263 RVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRC 327
            .|:.:|||||..||:.:.........:|.:||||....|:.:||||..|:..|:......:||.|
Mouse   264 LVSKISFTGSTATGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNAGQTC 328

  Fly   328 TTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGG 392
            ..:.|.:|...:||.||.:.....|:.: ::|:..|..|..||:..::.||..:..:.:|.:.|.
Mouse   329 VCSNRFLVQRGIHDSFVTKFAEAMKKSL-RVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVAKGA 392

  Fly   393 TVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSA 457
            ||..||...|..|.:.|||:::.:..|...:..|||.|:..::|....::|:...|..|.||:..
Mouse   393 TVVTGGKRHQSGGNFFEPTLLSNVTRDMLCITEETFGPLAPVIKFDKEEEAVAIANAAEVGLAGY 457

  Fly   458 IFTENIGQAFKWIGAKGSDCGIVNINTTTNG--AEIGGAFGGEKATGGGRESGSDAWKQY 515
            .::::..|.  |..|:..:.|:|.:|   .|  :.:...|||.|.:|.|||.......:|
Mouse   458 FYSQDPAQI--WRVAEQLEVGMVGVN---EGLISSVECPFGGVKQSGLGREGSKYGIDEY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	133/475 (28%)
Aldh5a1	NP_766120.1	SSADH	66..516	CDD:188167	131/460 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810