DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh4a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_780647.3	Gene:	Aldh4a1 / 212647	MGIID:	2443883	Length:	562	Species:	Mus musculus

Alignment Length:	477	Identity:	114/477 - (23%)
Similarity:	198/477 - (41%)	Gaps:	77/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 IAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELR--KYKEPLGKLVSLEVGKI 137
            :||....:...|...|..|:.|.|:|...|...|.::..:..|.|.  :..|.|.|.:   ||
Mouse    90 VAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTM---VG-- 149

  Fly   138 YSEGQGEVQEFIDICDYAVGLSRIYSGQLINSE---------RADHSILEAWRPL-GVVGVISAY 192
              :|:..:|..||.....:...|..:...:..|         ..:|::   :|.| |.|..||.:
Mouse   150 --QGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTV---YRGLEGFVAAISPF 209

  Fly   193 NFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP--VVTLCQGGTDVG 255
            || .|:.|..|......||.||||.:.:..|.|.|    |..:||...|||  :..:...|...|
Mouse   210 NF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYA----VYRILREAGLPPNIIQFVPADGPTFG 269

  Fly   256 QTLVADKRVNLVSFTGSCQTGRDVGVEVQ------RRFGKVILELGGNNALIIDESANVKMALDA 314
            .|:.:.:.:..::||||..|.:.:..:|.      |.|.::..|.||.|...:..||:|...:..
Mouse   270 DTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSG 334

  Fly   315 ALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVEN 379
            .|.......||:|:...|:.|.:.|..|....|:.::.::  |:|...|            :...
Mouse   335 TLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRI--KVGDPAE------------DFGT 385

  Fly   380 YKAAIAEAKSLGG--------------TVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAP 430
            :.:|:.:||:...              ::..||...:..|:||||.:|........::..|.|.|
Mouse   386 FFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGP 450

  Fly   431 I--VYIL---KAKNVDQAIEWNNEVEQGLSSAIFTEN---IGQAFKWIGAKGSDCGIVNINTTTN 487
            :  ||:.   |.:...|.::  :....||:.|:|.::   :.:|.:.:   .:..|...||..:.
Mouse   451 VLTVYVYPDDKYRETLQLVD--STTSYGLTGAVFAQDKAIVQEATRML---RNAAGNFYINDKST 510

  Fly   488 GAEIG-GAFGGEKATGGGRESG 508
            |:.:| ..|||.:|:|...:.|
Mouse   511 GSVVGQQPFGGARASGTNDKPG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	114/477 (24%)
Aldh4a1	NP_780647.3	ALDH_F4-17_P5CDH	31..552	CDD:143441	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900