Protein Alignment Aldh7A1 and ALDH1L2

DIOPT Version :10

• Sequence 1: NP_649099.1
• Gene: Aldh7A1 / 40097
• FlyBaseID: FBgn0036857
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001029345.2
• Gene: ALDH1L2 / 160428
• HGNCID: 26777
• Length: 923
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 151/544 - (27%)
• Similarity: 254/544 - (46%)
• Gaps: 59/544 - (10%)

  Fly     8 ISKLALPRRLVTQTASYSSS--SSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYDPG 70
            :.||....:.|.....|.|.  :..::..|...|:.....:.|:           |.:..:.:|.
Human   413 VRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADD-----------GKTYDTINPT 466

  Fly    71 TGQPIAKVRQGNVQELEHTIGLAVEAYK--QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLE 133
            .|..|.||...::.:::..:..|.:|::  :|.::.|..||.::.::.|.|.:.:|.|..:.:|:
Human   467 DGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALD 531

  Fly   134 VGKIYSEGQG-----EVQE---FIDICDYAVGLSRIYSGQLINSERADHSI-LEAWRPLGVVGVI 189
            .|.:|:....     .||.   |...||...|     |...||..|.:.:: .....||||..:|
Human   532 SGAVYTLALKTHIGMSVQTFRYFAGWCDKIQG-----STIPINQARPNRNLTFTKKEPLGVCAII 591

  Fly   190 SAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GT 252
            ..:|:|..:..|.:|..|..||:::.|.|..|||.::.    .||:..:...|. |:.:..| |.
Human   592 IPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALK----FAELSVKAGFPKGVINIIPGSGG 652

  Fly   253 DVGQTLVADKRVNLVSFTGSCQTGRDVGVE-VQRRFGKVILELGGNNALIIDESAN----VKMAL 312
            ..||.|.....:..:.||||...|:.:... ......||.|||||.:.|||.....    |:|.:
Human   653 IAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGM 717

  Fly   313 DAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGP----VHT 373
            .|..|    ..|:.|....|:.|.|.:||:||..:|.:.|::  |||..|:..|..||    .|.
Human   718 GAVFF----NKGENCIAAGRLFVEESIHDEFVTRVVEEIKKM--KIGDPLDRSTDHGPQNHKAHL 776

  Fly   374 QQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAK 438
            ::.::..:..:.|    |.|:.:||..:||.||::||||.|.:.....:...|:|.||:.|.|.:
Human   777 EKLLQYCETGVKE----GATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQ 837

  Fly   439 N--VDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKAT 501
            |  :|..::..|..|.||:|.:||.:|.:|. ::..| .:.|.|.|| |.|..::...|||.|.:
Human   838 NGDIDGVLQRANSTEYGLASGVFTRDINKAM-YVSEK-LEAGTVFIN-TYNKTDVAAPFGGVKQS 899

  Fly   502 GGGRESGSDAWKQYCKRATITVNH 525
            |.|::.|.:|..:|.|..|:|:.:
Human   900 GFGKDLGEEALNEYLKTKTVTLEY 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	143/499 (29%)
ALDH1L2	NP_001029345.2	Hydrolase domain. /evidence=ECO:0000250|UniProtKB:P28037	23..331
		FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:425746
		Aldehyde dehydrogenase domain. /evidence=ECO:0000250|UniProtKB:P28037	438..923		146/517 (28%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	146/516 (28%)