DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	596	Identity:	155/596 - (26%)
Similarity:	268/596 - (44%)	Gaps:	95/596 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRNISKLALPRRL-VTQTASYSSSSSYLIDQPE-YSFLKEL--GLERDNPGVY------------ 53
            :|::.:..||:.| |..:..:..|.:..:|... ...:|||  |||.:|..||
Human   337 VRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLL 401

  Fly    54 -----------------------------------SGQW---QGRGPSVTSYDPGTGQPIAKVRQ 80
                                               .|::   :|...|.| .:|..|..|.:|..
Human   402 VRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSET-INPTDGSVICQVSL 465

  Fly    81 GNVQELEHTIGLAVEAYK--QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEG-Q 142
            ..|.:::..:..|.:|::  :|.::.|..||.::.::.|.:.:::|.|..:.:|:.|.:|:.. :
Human   466 AQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALK 530

  Fly   143 GEVQEFIDICDYAVGLSRIYSGQL--INSERADHSI-LEAWRPLGVVGVISAYNFPNAVFGWNAA 204
            ..|...|....|..|......|..  ||..|.:.:: |....|:||.|:|..:|:|..:..|..|
Human   531 THVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTA 595

  Fly   205 IALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVGQTLVADKRVNLV 267
            ..|..||:|:.|.|..|||.::.    .||:..:..:|. ||.:..| |:.|||.|.....|..:
Human   596 ACLAAGNTVVIKPAQVTPLTALK----FAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKI 656

  Fly   268 SFTGSCQTGRDV-------GVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQ 325
            .||||.:.|:.:       .|:      ||.|||||.:.|||....::..|:...:.......|:
Human   657 GFTGSTEVGKHIMKSCAISNVK------KVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGE 715

  Fly   326 RCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGP----VHTQQNVENYKAAIAE 386
            .|....|:.|.:.:||:||:.:|.:.:::  |:|:.|:..|..||    .|..:.:|..:..:.|
Human   716 NCIAAGRLFVEDSIHDEFVRRVVEEVRKM--KVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKE 778

  Fly   387 AKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAK--NVDQAIEWNNE 449
                |.|:..|||.:.|.||:.||||.|.:.....:...|:|.|::.|.:..  ::|..:...|.
Human   779 ----GATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANA 839

  Fly   450 VEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQ 514
            .|.||:|.:||.:|.:|. ::..| ...|.|.:| |.|..::...|||.|.:|.|::.|..|..:
Human   840 TEFGLASGVFTRDINKAL-YVSDK-LQAGTVFVN-TYNKTDVAAPFGGFKQSGFGKDLGEAALNE 901

  Fly   515 YCKRATITVNH 525
            |.:..|:|..:
Human   902 YLRVKTVTFEY 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	141/546 (26%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949	16/63 (25%)
		ALDH_F1L_FTFDH	427..912	CDD:143458	139/504 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810