DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001343341.1	Gene:	Aldh1l1 / 107747	MGIID:	1340024	Length:	902	Species:	Mus musculus

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	259/533 - (48%)	Gaps:	45/533 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQW---QGRGPSVTSYDPGTGQPIAKV 78
            ||.:.......|..:|:..|.: :|:|.|:........|::   :| ..:.::.:|..|..|.:|
Mouse   391 LVRKLRGEDGESECVINYVEKA-VKKLTLQMPYQLFIGGEFVDAEG-AKTYSTINPTDGSVICQV 453

  Fly    79 RQGNVQELEHTIGLAVEAYKQ--WRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEG 141
            ....|.:::..:..|.||::.  |.::.|..||.::.::.|.:.:::|.|..:.:|:.|.:|:..
Mouse   454 SLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADLMEQHQEELATIEALDAGAVYTLA 518

  Fly   142 -QGEVQEFIDICDYAVG-LSRIYSGQL-INSERADHSI-LEAWRPLGVVGVISAYNFPNAVFGWN 202
             :..|...|....|..| ..:|....: ||..|.:.:: |....|:||.|::..:|:|..:..|.
Mouse   519 LKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWK 583

  Fly   203 AAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVGQTLVADKRVN 265
            .|..|..||:|:.|.|..|||.::.    .||:..:..:|. ||.:..| |:.|||.|.....|.
Mouse   584 TAACLAAGNTVVIKPAQVTPLTALK----FAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVR 644

  Fly   266 LVSFTGSCQTGRDV-------GVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTS 323
            .:.||||.:.|:.:       .|:      ||.|||||.:.|||....::..|:...:.......
Mouse   645 KIGFTGSTEVGKHIMKSCALSNVK------KVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNK 703

  Fly   324 GQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGP----VHTQQNVENYKAAI 384
            |:.|....|:.|.:.:|||||:::|.:..::  |||:.|:..|..||    .|.::.||..:..:
Mouse   704 GENCIAAGRLFVEDSIHDQFVQKVVEEVGKM--KIGNPLDRDTNHGPQNHEAHLRKLVEYCQRGV 766

  Fly   385 AEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAK--NVDQAIEWN 447
            .|    |.|:..|||.:.|.||:.:|||.|.:.....:...|:|.||:.|.:..  :||..:...
Mouse   767 KE----GATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRA 827

  Fly   448 NEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAW 512
            |..|.||:|.:||.:|.:|. ::..| ...|.|.:| |.|..::...|||.|.:|.|::.|..|.
Mouse   828 NATEFGLASGVFTRDINKAL-YVSDK-LQAGTVFVN-TYNKTDVAAPFGGFKQSGFGKDLGEAAL 889

  Fly   513 KQYCKRATITVNH 525
            .:|.:..|:|..:
Mouse   890 NEYLRIKTVTFEY 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	141/499 (28%)
Aldh1l1	NP_001343341.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		FDH_Hydrolase_C	206..306	CDD:187731
		PP-binding	325..391	CDD:306928	149/533 (28%)
		ALDH_F1L_FTFDH	417..902	CDD:143458	142/504 (28%)
		Aldehyde dehydrogenase	417..902		142/504 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810