DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nes and MBOAT1

DIOPT Version :9

Sequence 1:	NP_524157.2	Gene:	nes / 40093	FlyBaseID:	FBgn0026630	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001073949.1	Gene:	MBOAT1 / 154141	HGNCID:	21579	Length:	495	Species:	Homo sapiens

Alignment Length:	467	Identity:	107/467 - (22%)
Similarity:	193/467 - (41%)	Gaps:	77/467 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VGVPVEALRLLLTILAGYPVAALYQKFISV-IADKTVHHMFFAGCGAGLCYFNYGLDTYHSLIAI 84
            :|:|::.:..::..|.....|..::.::.. .....|.|......|.....|.:|..:.|..:.:
Human    27 LGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLV 91

  Fly    85 LTTYFLVLLLR----KKTQIFLAINF--VFHMSYLLLGYFYTSSNDYDILWTMPHCILVLRMIGY 143
            |..|.:::...    .:...|:|:.:  :.|:|.:.:.::...:.|:    :.|..|:..::...
Human    92 LMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDF----SGPLMIVTQKITTL 152

  Fly   144 GFDITDGLKEESE-LSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFVDGEFRQH 207
            .|.:.|||...:| ||.:|...|:|..||.||.|::.......:.||...|:.|.||::|: ..|
Human   153 AFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGK-HIH 216

  Fly   208 EGNVEAGVRRFG---------AGAFYLIVCQVGLRYLPDSYFLT-----PEFAQV--------SF 250
            ...:|...:|.|         .||   ::.::|:..:....|||     |....|        ||
Human   217 MKLLEVNWKRKGFHSLPEPSPTGA---VIHKLGITLVSLLLFLTLTKTFPVTCLVDDWFVHKASF 278

  Fly   251 VKRIYLLGFWAKFSLYKYISCWLLTEGALICIGLTYKGEDKNGQPDWSGCSNVKLKLLETGNTME 315
            ..|:..|....:.|..||...|.|.:......|..:.|.||||...|...||:.:..:||..:.:
Human   279 PARLCYLYVVMQASKPKYYFAWTLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFK 343

  Fly   316 HYVQSFNVNTNQWVGQYIYKRLKFLNNRTISYGAALGFL--AVWHGYHSGYYMTFLMEYMVVSTE 378
            .|::::|:.|..|:....|:|:.:       |...|.|:  |:|||.:.|||.|||...:|....
Human   344 MYLENWNIQTATWLKCVCYQRVPW-------YPTVLTFILSALWHGVYPGYYFTFLTGILVTLAA 401

  Fly   379 KQITRFYTKVVLPQWGHILNNSDIYKLLYFITLKSYNVVYMG--WCLT---------AFVFLKYE 432
            :.:...|..                   ||::.::...||..  |.:|         .||.|..|
Human   402 RAVRNNYRH-------------------YFLSSRALKAVYDAGTWAVTQLAVSYTVAPFVMLAVE 447

  Fly   433 RWIVVYGAVSYY 444
            ..|.:|.::.:|
Human   448 PTISLYKSMYFY 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nes	NP_524157.2	MBOAT	114..421	CDD:281107	82/333 (25%)
MBOAT1	NP_001073949.1	MBOAT	22..458	CDD:294479	106/464 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54526
OrthoDB	1	1.010	-	-		D881262at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830