DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nes and Lpcat3

DIOPT Version :9

Sequence 1:	NP_524157.2	Gene:	nes / 40093	FlyBaseID:	FBgn0026630	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_660112.1	Gene:	Lpcat3 / 14792	MGIID:	1315211	Length:	487	Species:	Mus musculus

Alignment Length:	458	Identity:	171/458 - (37%)
Similarity:	259/458 - (56%)	Gaps:	31/458 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDLPHNGLMDGIASGVGVPVEALRLLLTILAGYPVAALYQKFISVIADKTVHHMFFAGCGAGLCY 70
            |||..|.|    |:.:|...:||||:.:|..|||:|..|:.:: ...|..:.|:|....|..:.|
Mouse    24 EDLSLNKL----ATSLGASEQALRLIFSIFLGYPLALFYRHYL-FYKDSYLIHLFHTFTGLSIAY 83

  Fly    71 FNYGLDTYHSLIAILTTYFLVLLLRKKTQIFLAINFVFHMSYLLLGYFYTSSNDYDILWTMPHCI 135
            ||:|...||||:.:: ..||:|.|..:|...:.....|.|:|||.||:||::.||||.||||||:
Mouse    84 FNFGHQFYHSLLCVV-LQFLILRLMGRTVTAVITTLCFQMAYLLAGYYYTATGDYDIKWTMPHCV 147

  Fly   136 LVLRMIGYGFDITDGLKEESELSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFV 200
            |.|::||...|..||.|:.:.|:.:|::.|::..|||||:..||||...|||||||....|...|
Mouse   148 LTLKLIGLCIDYYDGGKDGNSLTSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212

  Fly   201 DGEFRQHEGNVE----AGVRRFGAGAFYLIVCQVGLRYLPDSYFLTPEFAQVSFVKRIYLLGFWA 261
            .|:.....|.:.    ..::|...|..||:...:...::.|.|.||.::....|..|...:..|.
Mouse   213 RGQLTDIPGKMPNSTIPALKRLSLGLVYLVGYTLLSPHITDDYLLTEDYDNRPFWFRCMYMLIWG 277

  Fly   262 KFSLYKYISCWLLTEGALICIGLTYKGEDKNGQPDWSGCSNVKLKLLETGNTMEHYVQSFNVNTN 326
            ||.||||::|||:|||..|..||.:.|.|:||...|..|:|:|:.|.||.......:.|||:|||
Mouse   278 KFVLYKYVTCWLVTEGVCILSGLGFNGFDENGTVRWDACANMKVWLFETTPRFNGTIASFNINTN 342

  Fly   327 QWVGQYIYKRLKFLNNRTISYGAALGFLAVWHGYHSGYYMTFLMEYMVVSTEKQITRFYTKVVLP 391
            .||.:||:||||||.|:.:|.|.:|.|||:|||.||||.:.|.||:::|..|||::
Mouse   343 AWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLICFQMEFLIVIVEKQVS--------- 398

  Fly   392 QWGHILNNSDIYKLL---------YFITLKSYNVVYMGWCLTAFVFLKYERWIVVYGAVSYYGFT 447
               .::.:|.....|         |::..::.:.::||:.:|||....:::|:.||.::.:.|..
Mouse   399 ---SLIRDSPALSSLASITALQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYRSIYFLGHV 460

  Fly   448 FLV 450
            |.:
Mouse   461 FFL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nes	NP_524157.2	MBOAT	114..421	CDD:281107	124/319 (39%)
Lpcat3	NP_660112.1	MBOAT	126..437	CDD:281107	125/322 (39%)
Lpcat3	NP_660112.1	Di-lysine motif	484..487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835170
Domainoid	1	1.000	250	1.000	Domainoid score	I2112
eggNOG	1	0.900	-	-		E1_COG5202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14678
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2412
Isobase	1	0.950	-	0	Normalized mean entropy	S2535
OMA	1	1.010	-	-		QHG54526
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006216
OrthoInspector	1	1.000	-	-		oto94807
orthoMCL	1	0.900	-	-		OOG6_106553
Panther	1	1.100	-	-	LDO	PTHR13906
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3447
SonicParanoid	1	1.000	-	-		X4491
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740