DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and RUVBL1

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_016862845.1	Gene:	RUVBL1 / 8607	HGNCID:	10474	Length:	467	Species:	Homo sapiens

Alignment Length:	414	Identity:	189/414 - (45%)
Similarity:	275/414 - (66%)	Gaps:	21/414 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIAGRCILLA 72
            ||:..|:.:||.:|||::|||||:...|:..:.|:|||::||.|.||:|::::..|:|||.:|||
Human     5 EVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLA 69

  Fly    73 GEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEETEIIEGE 137
            |.|.|||||:|:.:||.||::.||..|.|||:||.|:.|||.|.:..|::||:||||..|:.|||
Human    70 GPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGE 134

  Fly   138 VVEI---QIERPASGTGQKVGKVT--LKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKASGK 197
            |.|:   :.|.|..|.|:.:..|.  |||.:......|...|.|...||:::|||||.|:..||.
Human   135 VTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGA 199

  Fly   198 VNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHG---FLA---- 255
            |.:.||..|.|.::|....:  :|..|:|::.|:||::..||||::||.|:|..|   .|:
Human   200 VKRQGRCDTYATEFDLEAEE--YVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQ 262

  Fly   256 LFSGDTGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVV 320
            |......||..::|.:||..|.::.::|.||:.|||||:|||||||||||::|:|||||.:||:|
Human   263 LMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIV 327

  Fly   321 VMATNRGITRIRGT-NYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALT 384
            :.|:|||...|||| :..||||||:|||||::||||:.|:.:|:|:|:|||.:.|...:..:||.
Human   328 IFASNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALN 392

  Fly   385 ILTRIATDTSLR------YAIQLI 402
            .|..|.|.|:||      ..:|||
Human   393 HLGEIGTKTTLRSHDSMNMLVQLI 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	186/405 (46%)
		P-loop_NTPase	69..>113	CDD:304359	25/43 (58%)
		AAA	<267..358	CDD:99707	55/91 (60%)
RUVBL1	XP_016862845.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820