DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and ruvbl2

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_777285.1	Gene:	ruvbl2 / 317678	ZFINID:	ZDB-GENE-030109-1	Length:	463	Species:	Danio rerio

Alignment Length:	458	Identity:	350/458 - (76%)
Similarity:	413/458 - (90%)	Gaps:	1/458 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAETEKIEVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIA 65
            :|.|:..||||:|||||||||||||||||||.||.|.||||||||..:|||||::::|:::|:||
Zfish     5 VATTKVPEVRDITRIERIGAHSHIRGLGLDDALEPRQVSQGMVGQLASRRAAGLILEMIKDGQIA 69

  Fly    66 GRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEE 130
            ||.:|:||:|.|||||||:|:||:||.:||||:::||||:|||||||||||||.||:||||||||
Zfish    70 GRAVLIAGQPGTGKTAIAMGIAQSLGPDTPFTALAGSEIFSLEMSKTEALSQAFRKAIGVRIKEE 134

  Fly   131 TEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKAS 195
            |||||||||||||:|||:|||.||||:|||||||||.||||.|:||...||::|||||||||||:
Zfish   135 TEIIEGEVVEIQIDRPATGTGAKVGKLTLKTTEMETIYDLGTKMIESLSKERVQAGDVITIDKAT 199

  Fly   196 GKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGD 260
            ||::||||||||||||||.||||:|||||||||||||||||||:|||||||||||.|||||||||
Zfish   200 GKISKLGRSFTRARDYDAMGAQTQFVQCPEGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGD 264

  Fly   261 TGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATN 325
            |||||.|||:|||.||.||||||||||.|||||||||||||||||||||||||||::||::||||
Zfish   265 TGEIKSEVREQINAKVSEWREEGKAEIIPGVLFIDEVHMLDIECFSFLNRALESDLSPVLIMATN 329

  Fly   326 RGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIA 390
            |||||||||||:||||||||:|||::||.|.||:|||.::||||||||||..:..:|.|:||||.
Zfish   330 RGITRIRGTNYQSPHGIPIDMLDRLLIIATTPYTEKETRQILKIRCEEEDVELSEEAHTVLTRIG 394

  Fly   391 TDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKEYQDDYMFSEITEEV 455
            .:||||||||||:||.||||:|:.|||..||:|:||||||||.|||:.:|||||.::|:| |:..
Zfish   395 QETSLRYAIQLISTAGLVCRKRRGTEVQVEDIKRVYSLFLDEARSSQYMKEYQDSFLFNE-TQTS 458

  Fly   456 ERD 458
            :.|
Zfish   459 QMD 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	309/390 (79%)
		P-loop_NTPase	69..>113	CDD:304359	30/43 (70%)
		AAA	<267..358	CDD:99707	76/90 (84%)
ruvbl2	NP_777285.1	TIP49	21..412	CDD:283678	309/390 (79%)
ruvbl2	NP_777285.1	P-loop_NTPase	73..>117	CDD:304359	30/43 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592530
Domainoid	1	1.000	568	1.000	Domainoid score	I219
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4856
Inparanoid	1	1.050	706	1.000	Inparanoid score	I641
OMA	1	1.010	-	-		QHG53744
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	1	1.000	-	-		FOG0004276
OrthoInspector	1	1.000	-	-		oto38818
orthoMCL	1	0.900	-	-		OOG6_101635
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1272
SonicParanoid	1	1.000	-	-		X3010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800