DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and Ruvbl2

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_038960960.1	Gene:	Ruvbl2 / 292907	RGDID:	1306509	Length:	495	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	361/481 - (75%)
Similarity:	418/481 - (86%)	Gaps:	9/481 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AETEKI-EVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIA 65
            |.|.|: |:||||||||||||||||||||||.||.|..|||||||..||||||||::|:||||||
  Rat     8 AATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIA 72

  Fly    66 GRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEE 130
            ||.:|:||:|.|||||||:|||||||.:||||:::||||:||||||||||:||.|:|||||||||
  Rat    73 GRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEE 137

  Fly   131 TEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKAS 195
            |||||||||||||:|||:|||.||||:|||||||||.||||.|:||...|:|:|||||||||||:
  Rat   138 TEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKAT 202

  Fly   196 GKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGD 260
            ||::||||||||||||||.|:||:|||||:|||||||||||||:|||||||||||.|||||||||
  Rat   203 GKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGD 267

  Fly   261 TGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATN 325
            |||||.|||:|||.||.||||||||||.|||||||||||||||.|||||||||||||||::||||
  Rat   268 TGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATN 332

  Fly   326 RGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIA 390
            |||||||||:|:||||||||||||::|:.|.|||||:.|:||:|||||||..|..||.|:||||.
  Rat   333 RGITRIRGTSYQSPHGIPIDLLDRLLIVSTSPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIG 397

  Fly   391 TDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKEYQDDYMFSEITEEV 455
            .:|||||||||||.|:||||:||.|||..:|:|:||||||||:||::.:|||||.::|:|::|..
  Rat   398 LETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELSEYP 462

  Fly   456 ERDPAAGGGAKRRVEGGGGDAQPMEH 481
            ...|.        .||..|..|.:.|
  Rat   463 RLLPL--------WEGLHGSTQELPH 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	315/390 (81%)
		P-loop_NTPase	69..>113	CDD:304359	32/43 (74%)
		AAA	<267..358	CDD:99707	76/90 (84%)
Ruvbl2	XP_038960960.1	TIP49	18..454	CDD:224145	347/435 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350797
Domainoid	1	1.000	571	1.000	Domainoid score	I217
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4856
Inparanoid	1	1.050	712	1.000	Inparanoid score	I615
OMA	1	1.010	-	-		QHG53744
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	1	1.000	-	-		FOG0004276
OrthoInspector	1	1.000	-	-		oto97232
orthoMCL	1	0.900	-	-		OOG6_101635
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770