DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rept and ruvb-2

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_501067.1	Gene:	ruvb-2 / 177458	WormBaseID:	WBGene00020687	Length:	448	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	259/441 - (58%)
Similarity:	345/441 - (78%)	Gaps:	0/441 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAETEKIEVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIA 65
            ||..:.|.|:|:.::||...||||.||||:|.|||..||.|||||..||:|||::|:|::|||||
Worm     1 MATLDGINVKDIVKVERTSVHSHITGLGLNDRLEAEYVSGGMVGQVAARQAAGLIVKMIQEGKIA 65

  Fly    66 GRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEE 130
            ||.:|:.|||..||||||:.:::.||.:|||.|:..|||||.|::|||||:||.|:::|::||||
Worm    66 GRALLVTGEPGAGKTAIAIAISKELGEDTPFVSIVASEIYSNEINKTEALTQAFRRALGIQIKEE 130

  Fly   131 TEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKAS 195
            ||::||||:.::::|.|:|.|.||||:|::||:|||.||||:|:::..:|||:..||||.:||||
Worm   131 TEVLEGEVISLEVDRSANGMGPKVGKLTMRTTDMETIYDLGSKMVDACLKEKVMPGDVIQVDKAS 195

  Fly   196 GKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGD 260
            |:|.:|||||.|:.||||.|.:.:.||||:||:|||:|.||||.||:||||||||.|::||||||
Worm   196 GRVTRLGRSFNRSHDYDAMGPKVKLVQCPDGEIQKRRETVHTVCLHDIDVINSRTQGYVALFSGD 260

  Fly   261 TGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATN 325
            |||||.|||||||.|||||||||||:..||||||||.||||||||||||||:|.:::|:::||||
Worm   261 TGEIKAEVRDQINKKVLEWREEGKAKFVPGVLFIDEAHMLDIECFSFLNRAIEGELSPLIIMATN 325

  Fly   326 RGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIA 390
            |.|.::|||:..|.||||.|.||||:||..:||::::..:||.|||:||...:.|.||.:|.::.
Worm   326 RLIEKVRGTDVESAHGIPSDFLDRMLIINAIPYTKEDTAKILSIRCDEEGVKLQPTALDLLVKLQ 390

  Fly   391 TDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKE 441
            ..|||||.|.||..:.::..|.||..|.|:.:...|.||.|..||.|||.|
Worm   391 EATSLRYCIHLIAASEVIRIRSKAEIVTTDHIGSAYRLFFDTKRSEKILTE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	238/390 (61%)
		P-loop_NTPase	69..>113	CDD:304359	23/43 (53%)
		AAA	<267..358	CDD:99707	63/90 (70%)
ruvb-2	NP_501067.1	TIP49	17..408	CDD:283678	238/390 (61%)
ruvb-2	NP_501067.1	P-loop_NTPase	69..>122	CDD:304359	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164768
Domainoid	1	1.000	468	1.000	Domainoid score	I217
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4856
Inparanoid	1	1.050	544	1.000	Inparanoid score	I629
Isobase	1	0.950	-	0	Normalized mean entropy	S127
OMA	1	1.010	-	-		QHG53744
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	1	1.000	-	-		FOG0004276
OrthoInspector	1	1.000	-	-		oto18832
orthoMCL	1	0.900	-	-		OOG6_101635
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1272
SonicParanoid	1	1.000	-	-		X3010
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790