DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and MFRP

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_113621.1	Gene:	MFRP / 83552	HGNCID:	18121	Length:	579	Species:	Homo sapiens

Alignment Length:	205	Identity:	53/205 - (25%)
Similarity:	69/205 - (33%)	Gaps:	51/205 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLTSCRADGPLH------------SADHGMGGMGM--------------GGHGLDASPAPGYGV 53
            ||...|.|:.|.|            ..|||:...|.              |...|........||
Human   372 LLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGV 436

  Fly    54 --------------------PVIPKDPNLRCEEITIPMCRGIGYNMTSFPN-EMNHETQDEAGLE 97
                                |:.| .|.|.||.:.:.||.|:.||.|:||| .:...||:|....
Human   437 QWMCDMWRDCTDGSDDNCSGPLFP-PPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEV 500

  Fly    98 VHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERM 162
            :..:..|..:.|....:..||.:..|.| ......||.|||||:.|...|...:......||  .
Human   501 LSGYKSLTSLPCYQHFRRLLCGLLVPRC-TPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--F 562

  Fly   163 ACEHLPLHGD 172
            .|..||...|
Human   563 NCNRLPEAAD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	35/111 (32%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
MFRP	NP_113621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..143
		CUB	144..252	CDD:238001
		LDLa	260..294	CDD:238060
		CUB	301..411	CDD:238001	10/38 (26%)
		LDLa	421..454	CDD:238060	4/32 (13%)
		Fz	466..569	CDD:279700	33/105 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810