Protein Alignment fz2 and FZD9

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_003499.1
• Gene: FZD9 / 8326
• HGNCID: 4047
• Length: 591
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 255/609 - (41%)
• Similarity: 338/609 - (55%)
• Gaps: 98/609 - (16%)

  Fly    36 MGMGGHGLDA---SPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLE 97
            :..||..|:.   .|..|.|.        ..|:.:.||||||||||:|..||.:.|.:|.||..|
Human    16 LAAGGAALEIGRFDPERGRGA--------APCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAE 72

  Fly    98 VHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERM 162
            :.:|.|||:..|...|:|||||:|.|:|.:....|:|.||.:||:||..|||||:|::|.||:.:
Human    73 LAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSL 137

  Fly   163 ACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST 227
            .|..||...||..||||.|....||.     .....|.|......|.....|..|.|||||.
Human   138 DCARLPTRNDPHALCMEAPENATAGP-----AEPHKGLGMLPVAPRPARPPGDLGPGAGGSG--- 194

  Fly   228 STKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQ 292
                       .|:||  ||....|.|.||
Human   195 -----------TCENP--EKFQYVEKSRSC----------------------------------- 211

  Fly   293 RIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLS 357
                .|.|| |....|:|..:||||.:|:|:||.|||.||..|:.||:::..||:||||||:|||
Human   212 ----APRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLS 271

  Fly   358 ACYFMVAVGYLSRNFLQNEEIACD---GLL--LRE--SSTGPHSCTLVFLLTYFFGMASSIWWVI 415
            .||.:.::.:|.|.....:.:|||   |.|  ::|  .:||   |||||||.|:||||||:|||:
Human   272 MCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMASSLWWVV 333

  Fly   416 LSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHL 480
            |:.|||||||.|||:|||..|..|||:|||.:|.::::.:|.|..|.||.:.|:|||.:.:...|
Human   334 LTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAAL 398

  Fly   481 KTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVP 545
            ..|||.||..|||:|::||:.|||:||.||.::|.     .|...:||||||::||:||:|||||
Human   399 TGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFSILYTVP 458

  Fly   546 ATIVIGCYLYEAAYFEDW-IKALACPCAQVKGPGKK----------PLYSVLMLKYFMALAVGIT 599
            ||.||.||:||....:.| ::|...|||...|||.:          |..:|.|||.||:|.||||
Human   459 ATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGIT 523

  Fly   600 SGVWIWSGKTLESWRRFWRRLLGA 623
            ||||:||.||.::|:....|.:.|
Human   524 SGVWVWSSKTFQTWQSLCYRKIAA 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	59/118 (50%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	162/328 (49%)
		TM helix 1	316..341	CDD:320163	14/24 (58%)
		TM helix 2	350..371	CDD:320163	10/20 (50%)
		TM helix 3	396..422	CDD:320163	19/25 (76%)
		TM helix 4	439..455	CDD:320163	7/15 (47%)
		TM helix 5	477..506	CDD:320163	15/28 (54%)
		TM helix 6	531..558	CDD:320163	19/26 (73%)
		TM helix 7	579..604	CDD:320163	15/34 (44%)
FZD9	NP_003499.1	CRD_FZ	35..161	CDD:470581	61/133 (46%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	58..172		51/118 (43%)
		7tmF_FZD9	221..542	CDD:320164	162/328 (49%)
		TM helix 1	230..255	CDD:320164	14/24 (58%)
		TM helix 2	264..285	CDD:320164	10/20 (50%)
		TM helix 3	314..340	CDD:320164	19/25 (76%)
		TM helix 4	357..373	CDD:320164	7/15 (47%)
		TM helix 5	395..425	CDD:320164	15/29 (52%)
		TM helix 6	444..471	CDD:320164	19/26 (73%)
		TM helix 7	503..528	CDD:320164	15/24 (63%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537		2/4 (50%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	554..591