DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and FZD9

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_003499.1 Gene:FZD9 / 8326 HGNCID:4047 Length:591 Species:Homo sapiens


Alignment Length:609 Identity:255/609 - (41%)
Similarity:338/609 - (55%) Gaps:98/609 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 MGMGGHGLDA---SPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLE 97
            :..||..|:.   .|..|.|.        ..|:.:.||||||||||:|..||.:.|.:|.||..|
Human    16 LAAGGAALEIGRFDPERGRGA--------APCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAE 72

  Fly    98 VHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERM 162
            :.:|.|||:..|...|:|||||:|.|:|.:....|:|.||.:||:||..|||||:|::|.||:.:
Human    73 LAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSL 137

  Fly   163 ACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST 227
            .|..||...||..||||.|....||.     .....|.|......|.....|..|.|||||.   
Human   138 DCARLPTRNDPHALCMEAPENATAGP-----AEPHKGLGMLPVAPRPARPPGDLGPGAGGSG--- 194

  Fly   228 STKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQ 292
                       .|:||  ||....|.|.||                                   
Human   195 -----------TCENP--EKFQYVEKSRSC----------------------------------- 211

  Fly   293 RIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLS 357
                .|.|| |....|:|..:||||.:|:|:||.|||.||..|:.||:::..||:||||||:|||
Human   212 ----APRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLS 271

  Fly   358 ACYFMVAVGYLSRNFLQNEEIACD---GLL--LRE--SSTGPHSCTLVFLLTYFFGMASSIWWVI 415
            .||.:.::.:|.|.....:.:|||   |.|  ::|  .:||   |||||||.|:||||||:|||:
Human   272 MCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMASSLWWVV 333

  Fly   416 LSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHL 480
            |:.|||||||.|||:|||..|..|||:|||.:|.::::.:|.|..|.||.:.|:|||.:.:...|
Human   334 LTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAAL 398

  Fly   481 KTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVP 545
            ..|||.||..|||:|::||:.|||:||.||.::|.     .|...:||||||::||:||:|||||
Human   399 TGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFSILYTVP 458

  Fly   546 ATIVIGCYLYEAAYFEDW-IKALACPCAQVKGPGKK----------PLYSVLMLKYFMALAVGIT 599
            ||.||.||:||....:.| ::|...|||...|||.:          |..:|.|||.||:|.||||
Human   459 ATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGIT 523

  Fly   600 SGVWIWSGKTLESWRRFWRRLLGA 623
            ||||:||.||.::|:....|.:.|
Human   524 SGVWVWSSKTFQTWQSLCYRKIAA 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 59/118 (50%)
Frizzled 308..618 CDD:279827 162/327 (50%)
FZD9NP_003499.1 TM helix 1 230..255 CDD:320164 14/24 (58%)
TM helix 2 264..285 CDD:320164 10/20 (50%)
TM helix 3 314..340 CDD:320164 19/25 (76%)
TM helix 4 357..373 CDD:320164 7/15 (47%)
TM helix 5 395..425 CDD:320164 15/29 (52%)
TM helix 6 444..471 CDD:320164 19/26 (73%)
TM helix 7 503..528 CDD:320164 15/24 (63%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 532..537 2/4 (50%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 554..591
CRD_FZ 35..161 CDD:321937 61/133 (46%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 58..172 51/118 (43%)
7tmF_FZD9 221..542 CDD:320164 162/328 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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