DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and FZD8

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_114072.1	Gene:	FZD8 / 8325	HGNCID:	4046	Length:	694	Species:	Homo sapiens

Alignment Length:	769	Identity:	361/769 - (46%)
Similarity:	433/769 - (56%)	Gaps:	173/769 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICL 126
            |.|:|||:|:|:|||||.|..||:.||:||||||||||||||||||:||||||||||||||||||
Human    33 LACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICL 97

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |||.||||.||||||||::||||:|:||.|.||:||.|:.||..|:||.|||:. :.|:..:...
Human    98 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDY-NRTDLTTAAP 161

  Fly   192 S----------GGSGGSGSGSG--SGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQ 244
            |          |....||||.|  .|.:....|.|.||.|     |..:..|.||........|.
Human   162 SPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGG-----GDAAAPPARGGGGGGKARPP 221

  Fly   245 GEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFF 309
            |..|:..|..|.||:|::.:..|:              |..|..:...:||   ||.:||..|||
Human   222 GGGAAPCEPGCQCRAPMVSVSSER--------------HPLYNRVKTGQIA---NCALPCHNPFF 269

  Fly   310 SNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQ 374
            |.||:.|...||.|||.|||.||..|::||:||.||||||||||:||||||..|:||||.|....
Human   270 SQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAG 334

  Fly   375 NEEIACDG-----------------------------------------LLLRESSTGPHSCTLV 398
            :|::||.|                                         ..:|..:|||..||:|
Human   335 HEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVV 399

  Fly   399 FLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDG 463
            |||.|||||||||||||||.|||||||:|||||||..:||||||||||:|:|:|:|||.||:|||
Human   400 FLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDG 464

  Fly   464 DPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKL 528
            ||:.|||||||.:.|:|:.||||||.:||.|||.||:||||||||||||||||.|   ..|..||
Human   465 DPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDG---PTKTHKL 526

  Fly   529 EKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGP--GKKPLYSVLMLKYF 591
            ||||||:|:|:|||||||.:|:.|..||......|.....|||.:...|  .::|.|:|.|||||
Human   527 EKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYF 591

  Fly   592 MALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSA 656
            |.|.||||||||:||||||||||....|...|                        ..|..||..
Human   592 MCLVVGITSGVWVWSGKTLESWRSLCTRCCWA------------------------SKGAAVGGG 632

  Fly   657 AGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHVXHGESGGASTMGGGGGGGSTLGGGTLG 721
            ||:      |.|||                             ||..  |||||||
Human   633 AGA------TAAGG-----------------------------GGGP--GGGGGGG--------- 651

  Fly   722 HGTAMSSSTVGMGPLPGTLMHGASGGGVGGGNPGNVYGNGNNGVGGQNTAPGSV 775
                           ||      .|||.|||. |::|.:.:.|:..::....||
Human   652 ---------------PG------GGGGPGGGG-GSLYSDVSTGLTWRSGTASSV 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	88/118 (75%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	203/352 (58%)
FZD8	NP_114072.1	CRD_FZ8	31..155	CDD:143570	89/122 (73%)
		Palmitate-binding groove. /evidence=ECO:0000250	71..78		6/6 (100%)
		Wnt-binding. /evidence=ECO:0000250	95..100		4/4 (100%)
		Wnt-binding. /evidence=ECO:0000250	147..152		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..226		19/75 (25%)
		7tmF_FZD8	267..618	CDD:320378	204/353 (58%)
		TM helix 1	277..301	CDD:320378	13/23 (57%)
		TM helix 2	310..331	CDD:320378	15/20 (75%)
		TM helix 3	397..419	CDD:320378	19/21 (90%)
		TM helix 4	440..456	CDD:320378	11/15 (73%)
		TM helix 5	478..501	CDD:320378	14/22 (64%)
		TM helix 6	534..556	CDD:320378	13/21 (62%)
		TM helix 7	579..604	CDD:320378	17/24 (71%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	608..613		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..668		14/50 (28%)
		PDZ-binding	692..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I821
Isobase	1	0.950	-	0	Normalized mean entropy	S2842
OMA	1	1.010	-	-		QHG49270
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	1	1.000	-	-		FOG0003114
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106776
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4396
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.820