DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and FZD7

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_003498.1	Gene:	FZD7 / 8324	HGNCID:	4045	Length:	574	Species:	Homo sapiens

Alignment Length:	649	Identity:	280/649 - (43%)
Similarity:	366/649 - (56%)	Gaps:	137/649 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRG 74
            :..|||.|....:.|......||..|:.:..||.                    |:.|:||:|..
Human    15 LCALVLALLGALSAGAGAQPYHGEKGISVPDHGF--------------------CQPISIPLCTD 59

  Fly    75 IGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSV 139
            |.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|.. ..:.:|.|||:
Human    60 IAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSL 123

  Fly   140 CERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGS 204
            |||||.||..:|.::.|:||||:.||:.|:|| ...:|:.|         .:|.||||.|
Human   124 CERARQGCEALMNKFGFQWPERLRCENFPVHG-AGEICVGQ---------NTSDGSGGPG----- 173

  Fly   205 GGKRKQGGSGSGGSGA-----------------GGSSGSTSTKPCRGRNSKNCQNPQGEKASGKE 252
                       ||..|                 |.|.|       |||.:
Human   174 -----------GGPTAYPTAPYLPDLPFTALPPGASDG-------RGRPA--------------- 205

  Fly   253 CSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-------FFS 310
            ...||             .:|.::|    |:..|      |..|..:||.||: |       :|.
Human   206 FPFSC-------------PRQLKVP----PYLGY------RFLGERDCGAPCE-PGRANGLMYFK 246

  Fly   311 NDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQN 375
            .:|:.||.||:.:||.||..|||.|:.|:::|..||.||||||:|||.|||||||.::: .||..
Human   247 EEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVA-GFLLE 310

  Fly   376 EEIAC------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAIT 434
            :...|      ||.......|....||::|::.|||||||||||||||.|||||||:|||:|||.
Human   311 DRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIE 375

  Fly   435 KHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFL 499
            .:|||||||||.:|.|:::.:|.:..||||.:.|:||||..:.|.|:.||||||||||.|||:||
Human   376 ANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFL 440

  Fly   500 MAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW- 563
            :||||||||||:::|..     |.|.:||||||:|||:||||||||||||:.||.||.|:.|.|
Human   441 LAGFVSLFRIRTIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE 500

  Fly   564 -------IKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
                   .|:.|.||.....|...|.::|.|:||.|.:.||||:|.||||||||:|||||:.||
Human   501 RTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	61/118 (52%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	179/323 (55%)
FZD7	NP_003498.1	CRD_FZ7	45..169	CDD:143575	64/154 (42%)
		7tmF_FZD7	243..573	CDD:320374	181/328 (55%)
		TM helix 1	253..277	CDD:320374	12/23 (52%)
		TM helix 2	286..307	CDD:320374	14/21 (67%)
		TM helix 3	337..359	CDD:320374	16/21 (76%)
		TM helix 4	380..396	CDD:320374	9/15 (60%)
		TM helix 5	418..441	CDD:320374	16/22 (73%)
		TM helix 6	472..494	CDD:320374	17/21 (81%)
		TM helix 7	523..548	CDD:320374	11/24 (46%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	552..557		3/4 (75%)
		PDZ-binding	572..574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810