DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and FZD6

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001158087.1	Gene:	FZD6 / 8323	HGNCID:	4044	Length:	706	Species:	Homo sapiens

Alignment Length:	707	Identity:	213/707 - (30%)
Similarity:	316/707 - (44%)	Gaps:	167/707 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFL 117
            :|::.......||.||:|.|..:.||||.|||.|.|..|..|.:|:..|.||..::|||:::.||
Human    13 LPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFL 77

  Fly   118 CSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHL-------PLHGDPDN 175
            |..:.|.|:|..| .:|.||.:||:..|.|..::..:...|||.:.|:.|       |:..||
Human    78 CKAFVPTCIEQIH-VVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDP-- 139

  Fly   176 LCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNC 240
                   :||
Human   140 -------HTE------------------------------------------------------- 142

  Fly   241 QNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHH-------WYMNLTVQRIAGVP 298
                                  |||.::..:|..:......|.|       .|      :..|:.
Human   143 ----------------------FLGPQKKTEQVQRDIGFWCPRHLKTSGGQGY------KFLGID 179

  Fly   299 NCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMV 363
            .|..||...:|.:||.:||..:|...|..|.|:||.|..||:||..||:||||||::.|.||.:|
Human   180 QCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIV 244

  Fly   364 AVGYLSRNFLQNEEIAC----------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSF 418
            ::.|.. .||..:..||          |.::|...:   .:||::|:|.|||.||.::|||||:.
Human   245 SLMYFI-GFLLGDSTACNKADEKLELGDTVVLGSQN---KACTVLFMLLYFFTMAGTVWWVILTI 305

  Fly   419 TWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTF 483
            |||||||.||..|||.:.:.:||..||..|...:|.:|.::.|:||.|.|:|:||..:.|..:.|
Human   306 TWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYF 370

  Fly   484 VLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATI 548
            ||.||.:.:.:|.:.|:||.:||..:|.||:..|.     ..:||:|.|||||:||.||.||...
Human   371 VLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGR-----NQEKLKKFMIRIGVFSGLYLVPLVT 430

  Fly   549 VIGCYLY--------EAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIW 605
            ::|||:|        |..:..|..:....||........:|..::.|:||.|.|.|||::..|:.
Human   431 LLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVG 495

  Fly   606 SGKTLESWRRFWRRLLGAPDRTGANQAL-------IKQRPPIPHP---YAGS---------GMGM 651
            |.||...|..|::|.......:.:.:.|       :|....:.|.   |..|         .||.
Human   496 SKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGT 560

  Fly   652 PVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQ----PAASHVXHGESGGAST 704
            ..|:.|..         |.::||.|||.:|....|.:    |..| :...::.||||
Human   561 STGATANH---------GTSAVAITSHDYLGQETLTEIQTSPETS-MREVKADGAST 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	46/125 (37%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	129/327 (39%)
FZD6	NP_001158087.1	CRD_FZ6	20..146	CDD:143559	50/212 (24%)
		Frizzled	189..507	CDD:279827	128/326 (39%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..706		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810