DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and FZD4

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_036325.2	Gene:	FZD4 / 8322	HGNCID:	4042	Length:	537	Species:	Homo sapiens

Alignment Length:	622	Identity:	241/622 - (38%)
Similarity:	327/622 - (52%)	Gaps:	130/622 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RADGPLHSADHGMGGMGMG-GHGLD----ASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMT 80
            |..||  |.....||:|:. |..|.    ..||.|:|     .:...||:.|.|.||:.:|||:|
Human     4 RGAGP--SVPGAPGGVGLSLGLLLQLLLLLGPARGFG-----DEEERRCDPIRISMCQNLGYNVT 61

  Fly    81 SFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARS 145
            ..||.:.||.|.:|.|::..|.||::..||..|:|||||:|.|:|.|..:.|:..|..:|...:.
Human    62 KMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKR 126

  Fly   146 GCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQ 210
            .|.|:::::.|.|||.:.|...|...|.:::|||.|...|.
Human   127 RCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEV------------------------ 167

  Fly   211 GGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKA---SGKEC-SCSCRSPLIFLGKEQLLQ 271
                                            |...|.   .|:|| |....|......|..|
Human   168 --------------------------------PLPHKTPIQPGEECHSVGTNSDQYIWVKRSL-- 198

  Fly   272 QQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIALWSGLCFCSTLM 334
                                       ||.:.|  ....:|...|:|..:|:|:|:.|||.||..
Human   199 ---------------------------NCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAF 236

  Fly   335 TLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRE--SSTG 391
            |:.||:||:.||.||||||:|||.||.:.::.|:.|..:..|.|:||      .:|::|  .:||
Human   237 TVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTG 301

  Fly   392 PHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVL 456
               |.::|||.||||||||||||||:.|||||||||||:|||..||.|||:|||.||.|:::.:|
Human   302 ---CAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVIL 363

  Fly   457 LLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGA 521
            ::..||.|.:.|:|||||.|.|.|..||:||||.||||||.|:.||.|:||:|||.:::.
Human   364 IMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD----- 423

  Fly   522 GVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVL 586
            |.|.||||:||::||:||||||||||.||.||.||   ..:|        |..:........:|.
Human   424 GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--------ALFRYSADDSNMAVE 477

  Fly   587 MLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            |||.||:|.||||||:||||.|||.:|::...||:.:
Human   478 MLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	47/118 (40%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	165/317 (52%)
FZD4	NP_036325.2	CRD_FZ4	42..167	CDD:143557	48/124 (39%)
		7tmF_FZD4	209..509	CDD:320166	165/318 (52%)
		TM helix 1	218..243	CDD:320166	12/24 (50%)
		TM helix 2	252..273	CDD:320166	10/20 (50%)
		TM helix 3	303..329	CDD:320166	19/25 (76%)
		TM helix 4	346..362	CDD:320166	9/15 (60%)
		TM helix 5	384..413	CDD:320166	18/28 (64%)
		TM helix 6	433..460	CDD:320166	20/29 (69%)
		TM helix 7	470..495	CDD:320166	13/24 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	499..504		3/4 (75%)
		PDZ-binding	535..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820