DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and FZD4

DIOPT Version :10

Sequence 1:NP_001401042.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_036325.2 Gene:FZD4 / 8322 HGNCID:4042 Length:537 Species:Homo sapiens


Alignment Length:622 Identity:241/622 - (38%)
Similarity:327/622 - (52%) Gaps:130/622 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RADGPLHSADHGMGGMGMG-GHGLD----ASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMT 80
            |..||  |.....||:|:. |..|.    ..||.|:|     .:...||:.|.|.||:.:|||:|
Human     4 RGAGP--SVPGAPGGVGLSLGLLLQLLLLLGPARGFG-----DEEERRCDPIRISMCQNLGYNVT 61

  Fly    81 SFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARS 145
            ..||.:.||.|.:|.|::..|.||::..||..|:|||||:|.|:|.|..:.|:..|..:|...:.
Human    62 KMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKR 126

  Fly   146 GCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQ 210
            .|.|:::::.|.|||.:.|...|...|.:::|||.|...|.                        
Human   127 RCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEV------------------------ 167

  Fly   211 GGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKA---SGKEC-SCSCRSPLIFLGKEQLLQ 271
                                            |...|.   .|:|| |....|......|..|  
Human   168 --------------------------------PLPHKTPIQPGEECHSVGTNSDQYIWVKRSL-- 198

  Fly   272 QQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIALWSGLCFCSTLM 334
                                       ||.:.|  ....:|...|:|..:|:|:|:.|||.||..
Human   199 ---------------------------NCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAF 236

  Fly   335 TLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRE--SSTG 391
            |:.||:||:.||.||||||:|||.||.:.::.|:.|..:..|.|:||      .:|::|  .:||
Human   237 TVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTG 301

  Fly   392 PHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVL 456
               |.::|||.||||||||||||||:.|||||||||||:|||..||.|||:|||.||.|:::.:|
Human   302 ---CAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVIL 363

  Fly   457 LLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGA 521
            ::..||.|.:.|:|||||.|.|.|..||:||||.||||||.|:.||.|:||:|||.:::.     
Human   364 IMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD----- 423

  Fly   522 GVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVL 586
            |.|.||||:||::||:||||||||||.||.||.||   ..:|        |..:........:|.
Human   424 GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--------ALFRYSADDSNMAVE 477

  Fly   587 MLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            |||.||:|.||||||:||||.|||.:|::...||:.:
Human   478 MLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNS 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001401042.1 CRD_FZ5_like 63..182 CDD:143565 47/118 (40%)
7tmF_FZD5_FZD8-like 307..618 CDD:320163 165/318 (52%)
TM helix 1 316..341 CDD:320163 12/24 (50%)
TM helix 2 350..371 CDD:320163 10/20 (50%)
TM helix 3 396..422 CDD:320163 19/25 (76%)
TM helix 4 439..455 CDD:320163 9/15 (60%)
TM helix 5 477..506 CDD:320163 18/28 (64%)
TM helix 6 531..558 CDD:320163 20/26 (77%)
TM helix 7 579..604 CDD:320163 13/24 (54%)
FZD4NP_036325.2 CRD_FZ4 42..167 CDD:143557 48/124 (39%)
7tmF_FZD4 209..509 CDD:320166 165/318 (52%)
TM helix 1 218..243 CDD:320166 12/24 (50%)
TM helix 2 252..273 CDD:320166 10/20 (50%)
TM helix 3 303..329 CDD:320166 19/25 (76%)
TM helix 4 346..362 CDD:320166 9/15 (60%)
TM helix 5 384..413 CDD:320166 18/28 (64%)
TM helix 6 433..460 CDD:320166 20/29 (69%)
TM helix 7 470..495 CDD:320166 13/24 (54%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 499..504 3/4 (75%)
PDZ-binding 535..537
Blue background indicates that the domain is not in the aligned region.

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