DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and FZD5

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_003459.2	Gene:	FZD5 / 7855	HGNCID:	4043	Length:	585	Species:	Homo sapiens

Alignment Length:	678	Identity:	342/678 - (50%)
Similarity:	405/678 - (59%)	Gaps:	137/678 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPL 104
            |....||.||             .|:|||:|||||||||:|..||:.||:|||||||||||||||
Human    22 GRAAAASKAP-------------VCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPL 73

  Fly   105 VEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPL 169
            |||:|||||:||||||||||||.|||||||.||||||||::||:|:|:||.|.|||||:|:.||:
Human    74 VEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138

  Fly   170 HG-DPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR 233
            .| |.:.|||:.                                          :....:|.|.|
Human   139 LGRDAEVLCMDY------------------------------------------NRSEATTAPPR 161

  Fly   234 GRNSK-NCQNPQGEKASGKECS------CSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTV 291
            ...:| ....|.|..|||.||.      |.||.|.:              |::...|..|..:
Human   162 PFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFV--------------PILKESHPLYNKV-- 210

  Fly   292 QRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFL 356
             |...||||.:||..|.||.||:.||..||.|||.|||.||..|:.||:||.|||:||||||:||
Human   211 -RTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFL 274

  Fly   357 SACYFMVAVGYLSRNFLQNEEIACDGLLLRE------SSTGPHSCTLVFLLTYFFGMASSIWWVI 415
            ||||..|::|:|.|..:.:..:||.    ||      .:|||..||:||||.|||||||||||||
Human   275 SACYLCVSLGFLVRLVVGHASVACS----REHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVI 335

  Fly   416 LSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHL 480
            ||.|||||||:|||||||..::|||||||||||:|:|:..|.||:|||||:.|||||||.|.:.|
Human   336 LSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSL 400

  Fly   481 KTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVP 545
            :.|||.||.:||::||.||:|||||||||||||||     .|.|.|||||||||||||::|||||
Human   401 RGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVP 460

  Fly   546 ATIVIGCYLYEAAYFEDWIKALACPCA--QVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGK 608
            |:||:.|||||..|.|.|..||.|.|.  ....|..||.|.||||||||.|.|||||||||||||
Human   461 ASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGK 525

  Fly   609 TLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASV 673
            |:||||||..|....|.|                   |...|       |::.|..|.:|..|..
Human   526 TVESWRRFTSRCCCRPRR-------------------GHKSG-------GAMAAGDYPEASAALT 564

  Fly   674 AST-------SHHHLHHHVLKQPAASHV 694
            ..|       ::|       ||.:.|||
Human   565 GRTGPPGPAATYH-------KQVSLSHV 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	88/119 (74%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	206/317 (65%)
FZD5	NP_003459.2	TM helix 5	397..426	CDD:320377	16/28 (57%)
		TM helix 6	446..473	CDD:320377	21/26 (81%)
		TM helix 7	496..521	CDD:320377	19/24 (79%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	525..530		3/4 (75%)
		PDZ-binding	583..585		1/1 (100%)
		CRD_FZ5	29..156	CDD:143569	90/181 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..179		7/22 (32%)
		7tmF_FZD5	225..535	CDD:320377	207/318 (65%)
		TM helix 1	234..259	CDD:320377	15/24 (63%)
		TM helix 2	268..289	CDD:320377	13/20 (65%)
		TM helix 3	316..342	CDD:320377	22/25 (88%)
		TM helix 4	359..375	CDD:320377	12/15 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141198
Domainoid	1	1.000	415	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2590
Inparanoid	1	1.050	639	1.000	Inparanoid score	I821
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49270
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	1	1.000	-	-		FOG0003114
OrthoInspector	1	1.000	-	-		oto90246
orthoMCL	1	0.900	-	-		OOG6_106776
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4396
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800