Protein Alignment fz2 and SMO

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_005622.1
• Gene: SMO / 6608
• HGNCID: 11119
• Length: 787
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 179/672 - (26%)
• Similarity: 282/672 - (41%)
• Gaps: 184/672 - (27%)

  Fly    10 ILGLVLLL----------TSCRADGPLHSADHGMGGMGMGGHGLDASPAP----GYGVPVIPKDP 60
            :|||:|||          :|..|.||   .....||.......:...|.|    |...|
Human    14 LLGLLLLLLLGDPGRGAASSGNATGP---GPRSAGGSARRSAAVTGPPPPLSHCGRAAP------ 69

  Fly    61 NLRCEEITIPMCRG--IGYNMTSFPNEMNHETQDEA--------GL-EVHQFWPLVEIKCSPDLK 114
               ||.:...:|.|  :.|..||.....:.::|:||        || ...:.|.:::    |
Human    70 ---CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ----P--- 124

  Fly   115 FFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCME 179
             .||::|.|.| |:....|| .|::|:..|..||.:.::..  ||:.:.|       .||
Human   125 -LLCAVYMPKC-ENDRVELP-SRTLCQATRGPCAIVERERG--WPDFLRC-------TPD----- 172

  Fly   180 QPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNP- 243
                                                                   |..:.|.|.
Human   173 -------------------------------------------------------RFPEGCTNEV 182

  Fly   244 QGEK--ASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKG 306
            |..|  :||:     |..||:               ...:|..||.:        |..|||.|:.
Human   183 QNIKFNSSGQ-----CEVPLV---------------RTDNPKSWYED--------VEGCGIQCQN 219

  Fly   307 PFFSNDEKDFAGLWIALW---SGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACYFMVAVGY 367
            |.|:..|......:||.:   :|||   ||.||.||:.|.... :||...:.:::||:|:.::|:
Human   220 PLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGW 281

  Fly   368 LSRNFLQ--NEEIAC--DGLL-LRE-SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTW---FLA 423
            |:: |:.  ..||.|  ||.: |.| :|....||.::|::.|:..||..:|:|:|::.|   |.|
Human   282 LAQ-FMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKA 345

  Fly   424 AGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPL 488
            .|..:  :.::..:.||||..|.:|.|.:||:|.::.||||.:.|||:||..|..:...|||||:
Human   346 LGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPI 408

  Fly   489 FVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCY 553
            .:.|::|..||:.|.::||.|:|   ...|:.:...|.|:.:.|:|:|||..|......|...|:
Human   409 GLVLIVGGYFLIRGVMTLFSIKS---NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCH 470

  Fly   554 LYEAAYFEDWIKA----LACPCAQVKG-PGKKPL--------YSVLM--LKYFMALAVGITSGVW 603
            .|:.....:|.::    :.|......| |.|:|:        .|:|:  :..|.....||....|
Human   471 FYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTW 535

  Fly   604 IWSGKTLESWRRFWRRLLGAPD 625
            :|:..||..|||.|.||.|..|
Human   536 VWTKATLLIWRRTWCRLTGQSD 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	32/129 (25%)
		Frizzled	308..618	CDD:279827	107/337 (32%)
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	41/222 (18%)
		Frizzled	221..550	CDD:279827	107/337 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820