Protein Alignment fz2 and Fzd4

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_072145.1
• Gene: Fzd4 / 64558
• RGDID: 71017
• Length: 538
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 237/633 - (37%)
• Similarity: 326/633 - (51%)
• Gaps: 151/633 - (23%)

  Fly     5 RLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITI 69
            ||.:|:|.|:||                            ..||.|:|     .:...||:.|.|
  Rat    20 RLGLLLLQLLLL----------------------------QRPALGFG-----DEEERRCDPIRI 51

  Fly    70 PMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLP 134
            .||:.:|||:|..||.:.||.|.:|.|::..|.||::..||..|:|||||:|.|:|.|..:.|:.
  Rat    52 AMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIG 116

  Fly   135 VCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSG 199
            .|..:|...:..|.|:::::.|.||:.:.|...|...|.:::|||.|...|.
  Rat   117 PCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEV------------- 168

  Fly   200 SGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKA---SGKEC-SCSCRSP 260
                                                       |...|.   .|:|| |....|.
  Rat   169 -------------------------------------------PLPHKTPIQPGEECHSVGTNSD 190

  Fly   261 LIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIAL 323
            .....|..|                             ||.:.|  ....:|...|:|..:|:|:
  Rat   191 QYIWVKRSL-----------------------------NCVLKCGYDAGLYSRSAKEFTDIWMAV 226

  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------G 382
            |:.|||.||..|:.||:||:.||.||||||:|||.||.:.::.|:.|..:..|.|:||      .
  Rat   227 WASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEP 291

  Fly   383 LLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAW 445
            :|::|  .:||   |.::|||.||||||||||||||:.|||||||||||:|||..||.|||:|||
  Rat   292 VLIQEGLKNTG---CAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAW 353

  Fly   446 LIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIR 510
            .||.|:::.:|::..||.|.:.|:|||||.:.|.|..||:||||.||||||.|:.||.|:||:||
  Rat   354 AIPAVKTIVILIMRLVDADELTGLCYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIR 418

  Fly   511 SVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVK 575
            |.:::.     |.|.||||:||::||:||||||||||.||.||.||   ..:|        |..:
  Rat   419 SNLQKD-----GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--------ALFR 467

  Fly   576 GPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            ........:|.|||.||:|.||||||:||||.|||.:|::...||:.:
  Rat   468 YSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNS 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	46/118 (39%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	164/318 (52%)
		TM helix 1	316..341	CDD:320163	12/24 (50%)
		TM helix 2	350..371	CDD:320163	10/20 (50%)
		TM helix 3	396..422	CDD:320163	19/25 (76%)
		TM helix 4	439..455	CDD:320163	9/15 (60%)
		TM helix 5	477..506	CDD:320163	18/28 (64%)
		TM helix 6	531..558	CDD:320163	20/26 (77%)
		TM helix 7	579..604	CDD:320163	13/24 (54%)
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	47/124 (38%)
		7tmF_FZD4	210..510	CDD:320166	164/318 (52%)
		TM helix 1	219..244	CDD:320166	12/24 (50%)
		TM helix 2	253..274	CDD:320166	10/20 (50%)
		TM helix 3	304..330	CDD:320166	19/25 (76%)
		TM helix 4	347..363	CDD:320166	9/15 (60%)
		TM helix 5	385..414	CDD:320166	18/28 (64%)
		TM helix 6	434..461	CDD:320166	20/29 (69%)
		TM helix 7	471..496	CDD:320166	13/24 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505		3/4 (75%)
		PDZ-binding	536..538