DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and Fzd2

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_742032.2	Gene:	Fzd2 / 64512	RGDID:	71012	Length:	570	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	281/639 - (43%)
Similarity:	370/639 - (57%)	Gaps:	120/639 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCR 73
            |:|.|:||    .|.||  :..||..|:.:..||.                    |:.|:||:|.
  Rat    15 LLLPLLLL----PAAGP--AQFHGEKGISIPDHGF--------------------CQPISIPLCT 53

  Fly    74 GIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVC 136
            .|.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|  ||   :.:|.|
  Rat    54 DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLE---QAIPPC 115

  Fly   137 RSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSG 201
            ||:|||||.||..:|.::.|:||||:.|||.|.|| .:.:|:.| :::|.|:......:..||..
  Rat   116 RSICERARQGCEALMNKFGFQWPERLRCEHFPRHG-AEQICVGQ-NHSEDGTPALLTTAPPSGLQ 178

  Fly   202 SGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGK 266
            .|:||.       .||.|.||:....:|
  Rat   179 PGAGGT-------PGGPGGGGAPPRYAT------------------------------------- 199

  Fly   267 EQLLQQQSQMPMMHHPHHWYMNLTV-----QRIAGVPNCGIPCK------GPFFSNDEKDFAGLW 320
                        :.||.|....|.|     .:..|..:|..||:      ..|||.:|..||.||
  Rat   200 ------------LEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLW 252

  Fly   321 IALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC----- 380
            |..||.||..||..|:||:::|.:||:||||||:|||.||.||:|.|:: .|:..|.:.|
  Rat   253 ILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIA-GFVLQERVVCNERFS 316

  Fly   381 -DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAA 444
             ||.......|....||::|::.|||.|||||||||||.|||||||:|||:|||..:||||||||
  Rat   317 EDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAA 381

  Fly   445 WLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRI 509
            |.:|.|:::.:|.:..:|||.:.|:|:||..:.|.|:.||||||||||.|||:||:|||||||||
  Rat   382 WAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRI 446

  Fly   510 RSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKA 566
            |:::|..     |.|.:|||:||:|||:|||||||||||||.||.||.|:.|.|        .|:
  Rat   447 RTIMKHD-----GTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKS 506

  Fly   567 LACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            ||.||.....|...|.::|.|:||.|.|.||||||.||||||||.|||:|:.||
  Rat   507 LAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	64/120 (53%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	180/323 (56%)
Fzd2	NP_742032.2	CRD_FZ2	40..166	CDD:143573	68/150 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..194		10/34 (29%)
		7tmF_FZD2	239..568	CDD:320373	182/328 (55%)
		TM helix 1	249..273	CDD:320373	13/23 (57%)
		TM helix 2	282..303	CDD:320373	13/21 (62%)
		TM helix 3	333..355	CDD:320373	15/21 (71%)
		TM helix 4	376..392	CDD:320373	9/15 (60%)
		TM helix 5	414..437	CDD:320373	16/22 (73%)
		TM helix 6	468..490	CDD:320373	18/21 (86%)
		TM helix 7	519..544	CDD:320373	13/24 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	548..553		3/4 (75%)
		PDZ-binding	568..570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810