DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and SFRP5

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_003006.2	Gene:	SFRP5 / 6425	HGNCID:	10779	Length:	317	Species:	Homo sapiens

Alignment Length:	179	Identity:	61/179 - (34%)
Similarity:	85/179 - (47%)	Gaps:	43/179 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVLLLTSCRADGPLHSA-------DHGMGGMGMGGHGLDASPAPG--YGVPV----IPKDPNLRC 64
            |.|||      |.||.|       |:         :|..|.|..|  |..|.    ||.|
Human    15 LALLL------GALHWAPARCEEYDY---------YGWQAEPLHGRSYSKPPQCLDIPAD----- 59

  Fly    65 EEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDY 129
                :|:|..:||.....||.:.||:..|...:...:.||:..:|..|.:.||||::.|:||:
Human    60 ----LPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLD-- 118

  Fly   130 HKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCM 178
             :|:..|||:||..|:||||:|:.|.|.|||.:.|...||..|   ||:
Human   119 -RPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDND---LCI 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	43/116 (37%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
SFRP5	NP_003006.2	CRD_SFRP5	47..173	CDD:143553	48/132 (36%)
SFRP5	NP_003006.2	NTR_Sfrp1_like	178..303	CDD:239635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810