DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and Fzd1

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_067089.2	Gene:	Fzd1 / 58868	RGDID:	61916	Length:	642	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	279/658 - (42%)
Similarity:	362/658 - (55%)	Gaps:	127/658 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAP-------------GYGVPVIPKDPNLR 63
            ||:|||....|  ||...........:.|.|..|.|.|             |..:|     .:..
  Rat    53 GLLLLLWLLEA--PLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERGISIP-----DHGY 110

  Fly    64 CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--L 126
            |:.|:||:|..|.||.|..||.:.|..|::||||||||:|||:::||.:|||||||||.|:|  |
  Rat   111 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 175

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |   :.||.|||:|||||.||..:|.::.|:||:.:.||..|:|| ...||:.|
  Rat   176 E---QALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG-AGELCVGQ----------- 225

  Fly   192 SGGSGGSGSGSGS------GGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASG 250
              .:...|:.:.|      ....:.||.|..|...||:                     |....|
  Rat   226 --NTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGA---------------------GPVERG 267

  Fly   251 K-ECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP------F 308
            | .|..:.|.|.                        |:|   ....|..:||.||:..      :
  Rat   268 KFSCPRALRVPS------------------------YLN---YHFLGEKDCGAPCEPTKVYGLMY 305

  Fly   309 FSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFL 373
            |..:|..|:..||.:||.||..|||.|:.|:::|..||.||||||:|||.||..|||.|:: .||
  Rat   306 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIA-GFL 369

  Fly   374 QNEEIAC------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEA 432
            ..:.:.|      ||.......|....||::|::.|||.|||||||||||.|||||||:|||:||
  Rat   370 LEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEA 434

  Fly   433 ITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTT 497
            |..:|||||||||.:|.::::.:|.|..||||.:.|:|:||..|.|.|:.||||||||||.|||:
  Rat   435 IEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTS 499

  Fly   498 FLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFED 562
            ||:||||||||||:::|..     |.|.:||||||:|||:|||||||||||||.||.||.|:.:.
  Rat   500 FLLAGFVSLFRIRTIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQ 559

  Fly   563 W--------IKALACPCAQVKG-------PGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLES 612
            |        .|:.|.||..::|       |...|.::|.|:||.|.|.||||||.||||||||.|
  Rat   560 WERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNS 624

  Fly   613 WRRFWRRL 620
            ||:|:.||
  Rat   625 WRKFYTRL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	63/120 (53%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	178/330 (54%)
Fzd1	NP_067089.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99		5/24 (21%)
		CRD_FZ1	107..233	CDD:143574	64/142 (45%)
		Frizzled	305..629	CDD:279827	177/329 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		3/4 (75%)
		PDZ-binding	640..642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810