DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd8a

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_570993.2	Gene:	fzd8a / 58073	ZFINID:	ZDB-GENE-000328-3	Length:	579	Species:	Danio rerio

Alignment Length:	614	Identity:	324/614 - (52%)
Similarity:	392/614 - (63%)	Gaps:	81/614 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICL 126
            :.|:||.:|:|:|||||.|..||:.||:||||||||||||||||||:||||||||||||||||||
Zfish    28 ITCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICL 92

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |||.||||.||||||||::||||:|:||.|.||:||.|:.||:.|.||.|||:   |....|...
Zfish    93 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPDTLCMD---YNRTDSTTV 154

  Fly   192 S---GGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKEC 253
            |   .......|.:.:..|:|.|..|         .|....|||                   |.
Zfish   155 SPVLSKPTNYPSKAINPHKKKSGRPG---------VGPNKNKPC-------------------EP 191

  Fly   254 SCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAG 318
            .|.||:|::              |:....|..|..:   :...:|||.:||..|:|:.||:.|..
Zfish   192 GCQCRAPMV--------------PVNSDRHPLYNRV---KTGQIPNCAMPCHNPYFTQDERTFTA 239

  Fly   319 LWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGL 383
            .||.|||.|||.||..|:.||:||.||||||||||:||||||..|::||:.|....:|::||:
Zfish   240 FWIGLWSVLCFISTFATVATFLIDMERFKYPERPIIFLSACYMFVSIGYIVRLIAGHEKVACN-- 302

  Fly   384 LLRE--------SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYF 440
              ||        .:|||..||:||||.|||||||||||||||.|||||||:|||||||..:||||
Zfish   303 --REYDVEHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYF 365

  Fly   441 HLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVS 505
            ||||||||:::|:|||.||:|||||:.|||||||.|.|:|:.||||||.:||.|||.||:|||||
Zfish   366 HLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVS 430

  Fly   506 LFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACP 570
            ||||||||||     .|.|.|||||||||||||:|||||||||::.||.||....:.|.....|.
Zfish   431 LFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWEITHNCS 490

  Fly   571 CAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIK 635
            |. ::...|:|.|:|.||||||.|.||||||||.||||||||||.|..|.......:|.:.
Zfish   491 CL-LEQEIKRPDYAVFMLKYFMCLLVGITSGVWTWSGKTLESWRSFCTRCCWGSKGSGGSM---- 550

  Fly   636 QRPPIPHPYAGSGMGMPVGSAAGSLLATP 664
                    |:....|:...|...|.::.|
Zfish   551 --------YSDVSTGLTWRSGTASSVSCP 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	87/118 (74%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	204/317 (64%)
fzd8a	NP_570993.2	CRD_FZ8	26..150	CDD:143570	88/124 (71%)
		7tmF_FZD8	228..537	CDD:320378	205/318 (64%)
		TM helix 1	237..262	CDD:320378	14/24 (58%)
		TM helix 2	271..292	CDD:320378	13/20 (65%)
		TM helix 3	321..343	CDD:320378	19/21 (90%)
		TM helix 4	364..380	CDD:320378	11/15 (73%)
		TM helix 5	402..425	CDD:320378	14/22 (64%)
		TM helix 6	453..478	CDD:320378	19/24 (79%)
		TM helix 7	498..523	CDD:320378	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I613
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	628	1.000	Inparanoid score	I836
OMA	1	1.010	-	-		QHG49270
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	1	1.000	-	-		FOG0003114
OrthoInspector	1	1.000	-	-		otm24580
orthoMCL	1	0.900	-	-		OOG6_106776
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4396
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870