Protein Alignment fz2 and fzd9b

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_571586.1
• Gene: fzd9b / 58023
• ZFINID: ZDB-GENE-000906-4
• Length: 577
• Species: Danio rerio
• Alignment Length: 591
• Identity: 250/591 - (42%)
• Similarity: 341/591 - (57%)
• Gaps: 109/591 - (18%)

  Fly    63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLE 127
            :||.|.||||:|||||:|..||.|:|:.|.||.:::::|.||||..|...|:|||||:|.|:|.:
Zfish    36 KCEPIVIPMCQGIGYNLTRMPNFMDHDNQREAAIKLNEFAPLVEYGCDVHLRFFLCSLYAPMCTD 100

  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQP---SYTEAGSG 189
            .....:|.||.:||:||..|:|||:::::.|||.:.|..||...||:.||||.|   :.||
Zfish   101 QVSTSIPACRPMCEQARQECSPIMEKFNYAWPESLNCSKLPTRNDPNALCMEAPENDTKTE---- 161

  Fly   190 GSSGGSGGSGSGSGSG-----GKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKAS 249
                      :..|.|     .:.:|.|:|:..|  ||:.|.             |:||  ||..
Zfish   162 ----------TKKGEGMLPVPPRPRQPGAGNARS--GGTMGV-------------CENP--EKFQ 199

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEK 314
            ..|.|.:|                                       .|.|. .....|:|..:|
Zfish   200 YVEKSETC---------------------------------------APRCS-SAVDVFWSRQDK 224

  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379
            |||.:|:|:||.|||.||..|:.||::|..||:||||||:|||.||.:.:|.::.|:....|.||
Zfish   225 DFAFIWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYSVAFIIRSVAGAENIA 289

  Fly   380 CDG-----LLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHS 437
            ||.     .:::|  .|||   ||:|||:.|:||||||||||||:.|||||||.|||:|||..||
Zfish   290 CDRENGELYIIQEGLESTG---CTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIESHS 351

  Fly   438 QYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAG 502
            .|||:|||.||.::::.:|.:..|.||.:.|:||||:::...|..|||.||..||||||:|::.|
Zfish   352 SYFHMAAWGIPALKTIVILTMRKVAGDELTGLCYVGSMDVGALTGFVLVPLSCYLVIGTSFILTG 416

  Fly   503 FVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW-IKA 566
            ||:||.||.|:|.:     |...:||||||::|||:|:|||||||.||.||.||....:.| .:.
Zfish   417 FVALFHIRKVMKTE-----GTNTEKLEKLMVKIGIYSILYTVPATCVIICYFYERLNMDYWKFRG 476

  Fly   567 LACPCAQVKGPGKK----------PLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLL 621
            |...|...  ||::          |..:|.:||.||:|.||||||||:||.|||::|:....|.|
Zfish   477 LQSKCTTF--PGRRNEDCSLDSSVPTVAVFILKIFMSLVVGITSGVWVWSSKTLQTWQGLCSRKL 539

  Fly   622 GAPDRT 627
              .|||
Zfish   540 --TDRT 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	59/121 (49%)
		Frizzled	308..618	CDD:279827	165/327 (50%)
fzd9b	NP_571586.1	CRD_FZ9	33..159	CDD:143572	59/122 (48%)
		7tmF_FZD9	217..536	CDD:320164	165/328 (50%)
		TM helix 1	226..251	CDD:320164	14/24 (58%)
		TM helix 2	260..281	CDD:320164	10/20 (50%)
		TM helix 3	310..336	CDD:320164	19/25 (76%)
		TM helix 4	353..369	CDD:320164	8/15 (53%)
		TM helix 5	391..421	CDD:320164	16/29 (55%)
		TM helix 6	440..467	CDD:320164	19/26 (73%)
		TM helix 7	497..522	CDD:320164	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820