DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and fzd9b

DIOPT Version :10

Sequence 1:NP_001401042.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_571586.1 Gene:fzd9b / 58023 ZFINID:ZDB-GENE-000906-4 Length:577 Species:Danio rerio


Alignment Length:591 Identity:250/591 - (42%)
Similarity:341/591 - (57%) Gaps:109/591 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLE 127
            :||.|.||||:|||||:|..||.|:|:.|.||.:::::|.||||..|...|:|||||:|.|:|.:
Zfish    36 KCEPIVIPMCQGIGYNLTRMPNFMDHDNQREAAIKLNEFAPLVEYGCDVHLRFFLCSLYAPMCTD 100

  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQP---SYTEAGSG 189
            .....:|.||.:||:||..|:|||:::::.|||.:.|..||...||:.||||.|   :.||    
Zfish   101 QVSTSIPACRPMCEQARQECSPIMEKFNYAWPESLNCSKLPTRNDPNALCMEAPENDTKTE---- 161

  Fly   190 GSSGGSGGSGSGSGSG-----GKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKAS 249
                      :..|.|     .:.:|.|:|:..|  ||:.|.             |:||  ||..
Zfish   162 ----------TKKGEGMLPVPPRPRQPGAGNARS--GGTMGV-------------CENP--EKFQ 199

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEK 314
            ..|.|.:|                                       .|.|. .....|:|..:|
Zfish   200 YVEKSETC---------------------------------------APRCS-SAVDVFWSRQDK 224

  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379
            |||.:|:|:||.|||.||..|:.||::|..||:||||||:|||.||.:.:|.::.|:....|.||
Zfish   225 DFAFIWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYSVAFIIRSVAGAENIA 289

  Fly   380 CDG-----LLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHS 437
            ||.     .:::|  .|||   ||:|||:.|:||||||||||||:.|||||||.|||:|||..||
Zfish   290 CDRENGELYIIQEGLESTG---CTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIESHS 351

  Fly   438 QYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAG 502
            .|||:|||.||.::::.:|.:..|.||.:.|:||||:::...|..|||.||..||||||:|::.|
Zfish   352 SYFHMAAWGIPALKTIVILTMRKVAGDELTGLCYVGSMDVGALTGFVLVPLSCYLVIGTSFILTG 416

  Fly   503 FVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW-IKA 566
            ||:||.||.|:|.:     |...:||||||::|||:|:|||||||.||.||.||....:.| .:.
Zfish   417 FVALFHIRKVMKTE-----GTNTEKLEKLMVKIGIYSILYTVPATCVIICYFYERLNMDYWKFRG 476

  Fly   567 LACPCAQVKGPGKK----------PLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLL 621
            |...|...  ||::          |..:|.:||.||:|.||||||||:||.|||::|:....|.|
Zfish   477 LQSKCTTF--PGRRNEDCSLDSSVPTVAVFILKIFMSLVVGITSGVWVWSSKTLQTWQGLCSRKL 539

  Fly   622 GAPDRT 627
              .|||
Zfish   540 --TDRT 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001401042.1 CRD_FZ5_like 63..182 CDD:143565 59/121 (49%)
7tmF_FZD5_FZD8-like 307..618 CDD:320163 165/328 (50%)
TM helix 1 316..341 CDD:320163 14/24 (58%)
TM helix 2 350..371 CDD:320163 10/20 (50%)
TM helix 3 396..422 CDD:320163 19/25 (76%)
TM helix 4 439..455 CDD:320163 8/15 (53%)
TM helix 5 477..506 CDD:320163 16/28 (57%)
TM helix 6 531..558 CDD:320163 19/26 (73%)
TM helix 7 579..604 CDD:320163 14/34 (41%)
fzd9bNP_571586.1 CRD_FZ9 33..159 CDD:143572 59/122 (48%)
7tmF_FZD9 217..536 CDD:320164 165/328 (50%)
TM helix 1 226..251 CDD:320164 14/24 (58%)
TM helix 2 260..281 CDD:320164 10/20 (50%)
TM helix 3 310..336 CDD:320164 19/25 (76%)
TM helix 4 353..369 CDD:320164 8/15 (53%)
TM helix 5 391..421 CDD:320164 16/29 (55%)
TM helix 6 440..467 CDD:320164 19/26 (73%)
TM helix 7 497..522 CDD:320164 14/24 (58%)

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