DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd3b

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001074070.1	Gene:	fzd3b / 567746	ZFINID:	ZDB-GENE-070122-1	Length:	667	Species:	Danio rerio

Alignment Length:	731	Identity:	229/731 - (31%)
Similarity:	323/731 - (44%)	Gaps:	177/731 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRG 74
            ||.:|.||:...|   :|..       .:|.|.|                  ..||.|.:.||:.
Zfish    14 ILSVVSLLSGSMA---IHMD-------SVGSHSL------------------FTCESIGLRMCQD 50

  Fly    75 IGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSV 139
            :.||.|..||.:||..|..|.|.:..|.|:|.::|||||:.|||::|.|:|:|.....|| |||:
Zfish    51 LPYNNTFMPNLLNHYDQQTAALAMEPFHPMVNLQCSPDLRPFLCALYAPVCMEYGRVSLP-CRSL 114

  Fly   140 CERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGS 204
            |..|:..|..:|..:...|||.|.|...|   |.|.      ||..|
Zfish   115 CHHAKRDCQKLMDMFGVTWPEEMECTRFP---DCDE------SYPRA------------------ 152

  Fly   205 GGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQL 269
                                                                          |.|
Zfish   153 --------------------------------------------------------------EDL 155

  Fly   270 L-----QQQSQMPMMHHPHHWY-MNLTVQ-----RIAGVPNCGIPCKGPFFSNDEKDFAGLWIAL 323
            |     ..||.|.:......|. ..|.::     ...||.:|..||...:|..:|..||..:|.:
Zfish   156 LVIDDPTDQSPMSVQRDYGFWCPRELKMEPDLGYTFLGVRDCSPPCPNMYFRREELTFARYFIGV 220

  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRES 388
            .|.:|..:||.|..||:||..||:||||||:|.:.||.||::.:. ..||..:.:||:.....:.
Zfish   221 VSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLVFF-LGFLLEDRVACNSANPGQY 284

  Fly   389 ST-----GPH--SCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWL 446
            .|     |.|  :|||:|::.|||.||.|:|||||:.||||||..|||:|||.|.:..||.:||.
Zfish   285 KTSTVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWG 349

  Fly   447 IPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRS 511
            ||.:.::|:|.|:.::||.|.|:|:||..:...|:.||||||.:.:::|.:.|:||.|:|.|:|.
Zfish   350 IPGMLTIALLALNKIEGDNISGVCFVGVYDVQTLRWFVLAPLCLDVLVGVSLLLAGIVALNRVRM 414

  Fly   512 VIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALA 568
            .|..:     ....:||.|.|||||:|||||.||...|:||||||..|...|        .:...
Zfish   415 EIPLE-----KENQEKLVKFMIRIGVFSVLYLVPLLTVVGCYLYEQTYRSVWETTWVQERCREYH 474

  Fly   569 CPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQAL 633
            .||........:|...:.::||.|.|.|||.|..|:.|.||...|..|:.     ..|...:.|:
Zfish   475 IPCPFKVEQTSRPDLVLFLIKYLMVLVVGIPSVFWVGSKKTCFEWAGFFH-----GRRRKDSGAV 534

  Fly   634 IKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYT----QAGGASVASTSHHHLHHHV-----LKQP 689
            .:.|..:..|           ..|.|||..|.|    ::.|.|...||.|....|:     ::..
Zfish   535 HESRQVLQDP-----------DFAQSLLRDPNTPIVRKSRGTSTQGTSTHASSTHLAMLDDVRSK 588

  Fly   690 AASHVXHGESGGASTM 705
            |:|   |.:|...|::
Zfish   589 ASS--VHSKSSFHSSL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	47/118 (40%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	135/324 (42%)
fzd3b	NP_001074070.1	CRD_FZ	36..162	CDD:382974	54/233 (23%)
		7tmF_FZD3	204..524	CDD:320161	135/325 (42%)
		TM helix 1	213..238	CDD:320161	10/24 (42%)
		TM helix 2	247..268	CDD:320161	9/21 (43%)
		TM helix 3	299..325	CDD:320161	16/25 (64%)
		TM helix 4	342..364	CDD:320161	9/21 (43%)
		TM helix 5	378..403	CDD:320161	8/24 (33%)
		TM helix 6	431..456	CDD:320161	18/24 (75%)
		TM helix 7	485..510	CDD:320161	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810