DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd3a

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_005160805.1	Gene:	fzd3a / 565921	ZFINID:	ZDB-GENE-990415-225	Length:	686	Species:	Danio rerio

Alignment Length:	736	Identity:	227/736 - (30%)
Similarity:	325/736 - (44%)	Gaps:	160/736 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMC 72
            ||:..|..:||.|.|.....:..|.|                            ..||.||:.||
Zfish     2 VLLWALCSMLTVCMAINMEATGSHSM----------------------------FSCEPITLRMC 38

  Fly    73 RGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCR 137
            :|:.||.|..||.:||..|..|.|.:..|.|:|.::||.:::.|||::|.|:|.|.....|| ||
Zfish    39 QGLAYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLECSTEIRPFLCALYAPVCTEYGRVTLP-CR 102

  Fly   138 SVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGS 202
            .:|:||:|.|..:|:.:...||:.|.|...|       .|.|  ||..|
Zfish   103 RLCQRAKSDCYKLMEMFGVSWPDEMECSRFP-------ECEE--SYPRA---------------- 142

  Fly   203 GSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKE 267
                           .....||.||...|...:.......|:..|.
Zfish   143 ---------------IDLLPSSDSTEESPSAVQRDYGFWCPRELKI------------------- 173

  Fly   268 QLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCST 332
                         .|...|      ...||.:|..||...:|..||..||..:|.:.|.:|..:|
Zfish   174 -------------EPDLGY------SFMGVRDCSPPCPNMYFRKDELIFARYFIGVISIVCLSAT 219

  Fly   333 LMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD----GLLLRESST-GP 392
            |.|..||:||..||:||||||:|.:.||.||::.:. ..||..:.::|:    |.....:.| |.
Zfish   220 LFTFLTFLIDVGRFRYPERPIIFYAVCYMMVSLVFF-LGFLLEDRVSCNTASPGRFRASTITQGS 283

  Fly   393 H--SCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAV 455
            |  :|||:|:..|||.||.|:|||||:.||||||..|||:|||.|.:..||..||.:|...::.:
Zfish   284 HNKACTLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPGALTITL 348

  Fly   456 LLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVG 520
            :.::.::||.:.|:|:||..:...|:.|:|.||.:.:::|...|:||..:|.|:|..|..:
Zfish   349 MAMNKIEGDSMSGVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAALNRVRMEIPLE---- 409

  Fly   521 AGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALACPCAQVKGP 577
             ....|||.|.|||||:|||||.||...||||||||.::...|        .:....||......
Zfish   410 -KENQDKLVKFMIRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWETTWVQERCREYHIPCPFKVEK 473

  Fly   578 GKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFW-------------RRLLGAPDRTGA 629
            ..:|..::.::||.|.|.|||.|..|:.|.||...|..|:             |::|..||.|
Zfish   474 TSRPDIALFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFSGHRRKDSAVHESRQVLQEPDFT-- 536

  Fly   630 NQALIKQ-RPPIPHPYAGS---GMGMPVGSAAGSLLATP----YTQAGGA-SVASTSHHHLHHHV 685
             |.|::. ..|:.....|:   |......|...::|..|    .::||.. |.:|:.|..||...
Zfish   537 -QLLLRDPNTPVVRKSRGTSTQGTSTHASSTHLAMLDEPPSASTSRAGSTRSKSSSFHGSLHRSR 600

  Fly   686 LKQPAAS-------HVXHGES 699
            ..:..||       .| ||.|
Zfish   601 DGRYTASSFRGVEERVSHGSS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	46/118 (39%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	129/337 (38%)
fzd3a	XP_005160805.1	CRD_FZ3	26..152	CDD:143558	52/194 (27%)
fzd3a	XP_005160805.1	Frizzled	195..513	CDD:279827	128/323 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810