DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and col18a1a

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	763	Identity:	145/763 - (19%)
Similarity:	209/763 - (27%)	Gaps:	304/763 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LRCEEIT--IPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPI 124
            |||..:.  :|.|...|....|.||.:|..:.:|..:.:.::..|:...|...|::|.|.:.||.
Zfish   205 LRCLPVDSGLPFCTRRGVESFSVPNFLNQSSVEEVRMVLTEWAWLLRSGCHHSLEWFFCLLLTPR 269

  Fly   125 CLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSG 189
            |  .:...|..|||.||..:..|..::.:....    :.|:.||........|:...:..|.
Zfish   270 C--GHSGSLLPCRSSCEVLQDSCWTLLDEGRLP----VECKSLPEEKHDGYRCLSVSNLKEE--- 325

  Fly   190 GSSGGSGGS-----GSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKAS 249
                 ||.|     |....:|..:....:.|.|...|.||.                  .|:.|:
Zfish   326 -----SGVSLLQLIGDPPPNGVSKVFDQANSPGYVFGPSSN------------------VGQSAA 367

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGV-PNCGIPCKGPFFSNDE 313
            .                             |.|:.:|.:.::  |..: |....|  |..||
Zfish   368 A-----------------------------HLPNPFYRDFSL--IFNIKPTSSKP--GVIFS--- 396

  Fly   314 KDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEI 378
                                      |.|      |.:.|:::......|..|..|..|...|
Zfish   397 --------------------------ITD------PTQNIMYVGVKLSAVERGKQSIIFYYTE-- 427

  Fly   379 ACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLA 443
                         |.|.:......:......:||      |.|..:.|   ||.:   |.||:
Zfish   428 -------------PDSQSSYEAARFSVSSMLNIW------TRFSISVL---NEQV---SLYFN-- 465

  Fly   444 AWLIPTVQSVAVLLLSAVDGDPILGICYVGNL--NPDHLKTFVLAPLFVYLVIGTTFLMAGFVSL 506
                             .|.||     .|.|.  :||.:.....|.:||
Zfish   466 -----------------CDSDP-----QVVNFERSPDDMDMDAGAGVFV---------------- 492

  Fly   507 FRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTV--PATIVIGCYLYEAAYFEDWIKALAC 569
                       |..:|...||.      :|:...|...  |......|...|..|..:     |.
Zfish   493 -----------GHASGADPDKF------LGVIGDLRVSRDPGAAERHCEEEEDDYATE-----AS 535

  Fly   570 PCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALI 634
            ......|.|::|                                         :|.:.....:..
Zfish   536 GDYGASGDGEQP-----------------------------------------SPVQPTPPSSRP 559

  Fly   635 KQRP------PIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASH 693
            .|||      ||..|        ||                               :.::|....
Zfish   560 IQRPPVISRDPIQRP--------PV-------------------------------ISREPIQQT 585

  Fly   694 VXHGESGGASTMGGGGGGGSTLGGGTLGHGTAMSSSTVGMGPLPGTL-MHGASGGGVGGGNPGNV 757
            | .||.|.....|..|..|.....|.:|.|:.....:.|...:||.. |.|.||.|.    ||:
Zfish   586 VARGEKGDRGEKGAKGDRGLAGPKGDVGSGSVSGGGSKGDKGVPGEKGMKGTSGFGY----PGS- 645

  Fly   758 YGNGNNGVGGQNTAPGSVIDSRAV------SVV--VTLP-GGPGAQHP 796
              .|:.|..|....||....|..|      |||  ||.| |.||.|.|
Zfish   646 --KGDRGPPGPPGPPGPQGPSAEVEVRGDGSVVQKVTGPRGPPGPQGP 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	29/120 (24%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	47/313 (15%)
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	35/148 (24%)
		LamG	327..516	CDD:328935	57/358 (16%)
		Collagen	816..860	CDD:189968
		Collagen	<937..980	CDD:189968
		Collagen	959..1055	CDD:189968
		Endostatin	1471..1639	CDD:310825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810