DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd9a

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_003198734.2	Gene:	fzd9a / 557447	ZFINID:	ZDB-GENE-060531-77	Length:	581	Species:	Danio rerio

Alignment Length:	589	Identity:	248/589 - (42%)
Similarity:	341/589 - (57%)	Gaps:	113/589 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLE 127
            :||.||||||:|||||||..||.:|:|:|:||.:::::|.|||:..|...|:|||||:|.|:|.|
Zfish    35 KCEPITIPMCQGIGYNMTRMPNLLNYESQEEASIKLNEFAPLVKYGCDIHLQFFLCSLYVPMCAE 99

  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSS 192
            .....:|.||.:||:||..|:|||:|:||.||:.:.|..||.:.||:.||:|.|.
Zfish   100 QVSASIPACRPMCEQARQRCSPIMEQFSFSWPDSLDCSKLPTNNDPNALCIEAPE---------- 154

  Fly   193 GGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRN-----------SKNCQNPQGE 246
                     :.:..:.|:|            .|.....| |.|.           |::|:||:..
Zfish   155 ---------NDTQPETKKG------------EGMLPVPP-RSRQPTTVSGRISSISQSCENPEKF 197

  Fly   247 KASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSN 311
            :...|..||:                                         |.| .|....::|.
Zfish   198 QYVDKSESCA-----------------------------------------PRC-TPTVDVYWSR 220

  Fly   312 DEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNE 376
            .:||||.:|:.:||.|||.||..|:.||::|.:||:||||||:|||.||.:.:|.::.|:....|
Zfish   221 QDKDFAFIWMVVWSTLCFVSTAFTVLTFLLDPQRFQYPERPIIFLSMCYNIYSVAFIIRSVAGAE 285

  Fly   377 EIACDG-----LLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAIT 434
            .||||.     .::||  .|||   ||:|||:.|:||||||||||||:.|||||||.|||:|||.
Zfish   286 NIACDRENGELYIIREGLESTG---CTIVFLILYYFGMASSIWWVILTLTWFLAAGRKWGHEAIE 347

  Fly   435 KHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFL 499
            .||.|||:|||.||.|:::.:|.:..|.||.:.|:||||:::...|..|||.||..||::||:|:
Zfish   348 AHSSYFHMAAWGIPAVKTIVILTMRKVAGDELTGLCYVGSMDSSALTGFVLIPLSCYLIVGTSFI 412

  Fly   500 MAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW- 563
            :.|||:||.||.::|.     .|...:||||||::||:||:||||||||||.||.||....|.|
Zfish   413 LTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFSILYTVPATIVIICYFYERLNMEYWK 472

  Fly   564 IKALACPCAQVKGPGKK----------PLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWR 618
            .:||...|  |..||::          |..:|.|||.||:|.||||||||:||.|||::|:....
Zfish   473 FRALENKC--VSFPGRRSDDCSLDSSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCN 535

  Fly   619 RLLG 622
            |.||
Zfish   536 RRLG 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	61/118 (52%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	167/327 (51%)
fzd9a	XP_003198734.2	CRD_FZ	32..157	CDD:321937	62/140 (44%)
		7tmF_FZD9	216..535	CDD:320164	167/328 (51%)
		TM helix 1	225..250	CDD:320164	13/24 (54%)
		TM helix 2	259..280	CDD:320164	10/20 (50%)
		TM helix 3	309..335	CDD:320164	19/25 (76%)
		TM helix 4	352..368	CDD:320164	9/15 (60%)
		TM helix 5	390..420	CDD:320164	14/29 (48%)
		TM helix 6	439..466	CDD:320164	20/26 (77%)
		TM helix 7	496..521	CDD:320164	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920