Protein Alignment fz2 and fzd7

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001016741.1
• Gene: fzd7 / 549495
• XenbaseID: XB-GENE-483731
• Length: 548
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 270/637 - (42%)
• Similarity: 356/637 - (55%)
• Gaps: 138/637 - (21%)

  Fly    17 LTSCRADGPLHSAD--HGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNM 79
            |..|....|..||.  ||..|:.:..||.                    |:.|:||:|..|.||.
 Frog     7 LLFCLLLQPSPSAQQYHGEKGISVPDHGF--------------------CQPISIPLCTDIAYNQ 51

  Fly    80 TSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVCRSVCER 142
            |..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|  ||   :.:|.|||:|||
 Frog    52 TIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLE---QAIPPCRSLCER 113

  Fly   143 ARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGK 207
            ||.||..:|.::.|:||||:.||:.|:|
 Frog   114 ARQGCEALMNKFGFQWPERLRCENFPIH------------------------------------- 141

  Fly   208 RKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLI--------FL 264
                       |||        :.|.|:|:.: .:|.|..|.        .:|.:        .|
 Frog   142 -----------GAG--------EICVGQNTSD-NSPSGPTAR--------PTPYLPDSITFHPHL 178

  Fly   265 GKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-------FFSNDEKDFAGLWIA 322
            .::....:|.::|    |:..|      |..|..:||.||: |       :|..:|..||.||:.
 Frog   179 NRDFTCPRQLKVP----PYLGY------RFLGEKDCGAPCE-PGKANGLMYFKEEEVRFARLWVG 232

  Fly   323 LWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC------D 381
            :|:.||..|||.|:.|:::|..||.||||||:|||.|||||||.| :..||..|...|      |
 Frog   233 IWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAY-TAGFLLEERGVCVERFSED 296

  Fly   382 GLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWL 446
            ........|....||::|::.|||||||||||||||.|||||||:|||:|||..:|||||||||.
 Frog   297 SYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWA 361

  Fly   447 IPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRS 511
            :|.|:::.:|.:..||||.:.|:||||..:.|.|:.||||||||||.|||:||:||||||||||:
 Frog   362 VPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRT 426

  Fly   512 VIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALA 568
            ::|..     |.|.:||||||:|||:|||:||||||||:.||.||.|:.:.|        .|..|
 Frog   427 IMKHD-----GTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTWLVQTCKGFA 486

  Fly   569 CPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            .||.........|.::|.|:||.|.:.|||||..||||||||:|||||:.||
 Frog   487 VPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	60/120 (50%)
		Frizzled	308..618	CDD:279827	176/323 (54%)
fzd7	NP_001016741.1	CRD_FZ7	32..156	CDD:143575	68/203 (33%)
		Frizzled	218..536	CDD:279827	176/323 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000255	546..548

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910