Protein Alignment fz2 and fzd2

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001008449.1
• Gene: fzd2 / 493345
• XenbaseID: XB-GENE-487022
• Length: 553
• Species: Xenopus tropicalis
• Alignment Length: 620
• Identity: 267/620 - (43%)
• Similarity: 352/620 - (56%)
• Gaps: 133/620 - (21%)

  Fly    31 HGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAG 95
            ||..|:.:..||.                    |:.|:||:|..|.||.|..||.:.|..|::||
 Frog    27 HGEKGISVPEHGF--------------------CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAG 71

  Fly    96 LEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVCRSVCERARSGCAPIMQQYSFEW 158
            ||||||:|||:::||.:|:|||||||.|:|  ||   :.:|.|||:|||||.||..:|.::.|:|
 Frog    72 LEVHQFYPLVKVQCSSELRFFLCSMYAPVCTVLE---QAIPPCRSICERARHGCEALMNKFGFQW 133

  Fly   159 PERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGS 223
            |||:.||:.|.|| .:.:|:                                   |...|..||.
 Frog   134 PERLRCENFPRHG-AEQICV-----------------------------------GQNHSEDGGP 162

  Fly   224 SGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHW--- 285
            :..|::.|..|       .|               .|.|:             ..:.||.|.
 Frog   163 TLLTTSPPHHG-------TP---------------GPPIY-------------ATLDHPFHCPRV 192

  Fly   286 -----YMNLTVQRIAGVPNCGIPCKGP------FFSNDEKDFAGLWIALWSGLCFCSTLMTLTTF 339
                 |:|   .|..|..:|..||:..      |||.||..||.:||.:||.||..||..|:||:
 Frog   193 LKVPSYLN---YRFLGEKDCAAPCEPSKNDGFMFFSQDEIRFARVWILIWSVLCCASTFFTVTTY 254

  Fly   340 IIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRESSTGPHSCTLV 398
            ::|.:||:||||||:|||.||.||:|.|:: .|:...::.|:      |.......|....||::
 Frog   255 LVDMQRFRYPERPIIFLSGCYTMVSVAYIA-GFVLGNKVVCNENFSEGGYKTVVQGTKKEGCTIL 318

  Fly   399 FLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDG 463
            |::.|||.|||||||||||.|||||||:|||:|||..:|||||||||.:|.|:::.:|.:..:||
 Frog   319 FMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDG 383

  Fly   464 DPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKL 528
            |.:.|:|:||..|.|.|:.||||||||||.|||:||:||||||||||:::|..     |.|.:||
 Frog   384 DLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHD-----GTKTEKL 443

  Fly   529 EKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALACPCAQVKGPGKKPLYSV 585
            |:||:|||:|||||||||||||.||.||.|:.|.|        .|:||.||.....|...|.::|
 Frog   444 ERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQNCKSLAIPCPLQYTPRMTPDFTV 508

  Fly   586 LMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            .|:||.|.|.||||||.||||||||.|||:|:.||
 Frog   509 YMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	61/120 (51%)
		Frizzled	308..618	CDD:279827	179/323 (55%)
fzd2	NP_001008449.1	Frizzled	223..540	CDD:279827	178/322 (55%)
		CRD_FZ2	36..162	CDD:143573	66/184 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000