Protein Alignment fz2 and fzd6

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_956855.2
• Gene: fzd6 / 393533
• ZFINID: ZDB-GENE-040426-1451
• Length: 617
• Species: Danio rerio
• Alignment Length: 646
• Identity: 204/646 - (31%)
• Similarity: 287/646 - (44%)
• Gaps: 174/646 - (26%)

  Fly     8 VLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMC 72
            :|.|.::|||.||.:                  |.|                  ..||.:.:..|
Zfish     4 LLCLCVLLLLESCVS------------------HTL------------------FTCEPVQVQWC 32

  Fly    73 RGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKP----- 132
            ..:.||.|.|||.:.|..||.|.:.:.:|.|||.::||||...|||..:.|.|....|..
Zfish    33 LDMPYNTTFFPNMLEHYDQDIAAVRMKEFMPLVSVRCSPDAHLFLCQAFVPECRTHTHSQTHTHV 97

  Fly   133 LPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGG 197
            |..||..|||.||.|..:|..:...||..:.||.|.                      |.|||..
Zfish    98 LRPCRERCERVRSDCRAVMHTFDISWPSELQCERLE----------------------SCGGSAV 140

  Fly   198 SGSGSGSGGKRKQGGSGSGGSGAG-----------GSSGSTSTKPCRGRNSKNCQNPQGEKASGK 251
            ..:.:|      :.|:||.....|           |.|||
Zfish   141 DVTTAG------RSGAGSSPRDLGFWCPLQLKLRPGQSGS------------------------- 174

  Fly   252 ECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDF 316
                       ||                               |.|:|..||:..|.:..|:..
Zfish   175 -----------FL-------------------------------GAPDCAPPCENMFLTAAEQHL 197

  Fly   317 AGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD 381
            |.|:|.:.|.:|.|:||.|..||::|.:||:||||||||:|.||..|::.|| ..|:....:||.
Zfish   198 ARLFIGVCSVVCLCATLFTFLTFLMDAQRFRYPERPIVFISVCYCAVSLLYL-LGFMLGPSVACG 261

  Fly   382 G---------LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHS 437
            .         ::|...|.|   |:|:|.|.||...|..:|||||:.|||||||.||..|||.|.:
Zfish   262 APGRPGGVWTVVLGARSRG---CSLLFTLLYFCSTAGMLWWVILTITWFLAAGPKWSCEAIQKQA 323

  Fly   438 QYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAG 502
            .:||.|.|.:|.|.::.:|.|..|:||.|.|:|:.|..:...|:.|::|||.:.:::|...|:||
Zfish   324 LWFHAAGWGVPAVLTLLLLALGKVEGDGISGVCFTGLYDLTALRWFLVAPLALAVLLGLALLLAG 388

  Fly   503 FVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYE----AAYFEDW 563
            .|:|.|:|.||:..     .:...||::.|||||:||.||.:|..:::||||||    ..:...|
Zfish   389 IVALNRVRQVIQHD-----QLNQQKLKRFMIRIGVFSGLYLLPLLLLLGCYLYEMTQRRVWESSW 448

  Fly   564 I----KALACPCAQVKGPG-KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRR 619
            :    :..:.|||:....| :.|..|:.:|||.|.|||||.:..|:.|.||...|..|.||
Zfish   449 VNRHCQEFSIPCARTSSGGVQHPGLSLFLLKYLMTLAVGIPAVFWVSSRKTCSRWASFCRR 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	42/123 (34%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	131/328 (40%)
		TM helix 1	316..341	CDD:320163	11/24 (46%)
		TM helix 2	350..371	CDD:320163	12/20 (60%)
		TM helix 3	396..422	CDD:320163	13/25 (52%)
		TM helix 4	439..455	CDD:320163	6/15 (40%)
		TM helix 5	477..506	CDD:320163	10/28 (36%)
		TM helix 6	531..558	CDD:320163	16/30 (53%)
		TM helix 7	579..604	CDD:320163	11/24 (46%)
fzd6	NP_956855.2	None