DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and Fzd8

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_001037716.1 Gene:Fzd8 / 364754 RGDID:1560525 Length:684 Species:Rattus norvegicus


Alignment Length:765 Identity:355/765 - (46%)
Similarity:430/765 - (56%) Gaps:175/765 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICL 126
            |.|:|||:|:|:|||||.|..||:.||:||||||||||||||||||:||||||||||||||||||
  Rat    33 LACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICL 97

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |||.||||.||||||||::||||:|:||.|.||:||.|:.||..|:||.|||:. :.|:..:...
  Rat    98 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDY-NRTDLTTAAP 161

  Fly   192 S------GGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST-STKPCRGRNSKNCQNPQGEKAS 249
            |      ....|....||||..|..|.......|:...||.| :..|.||..::    |.|..|:
  Rat   162 SPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKAR----PPGGGAA 222

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEK 314
            ..|..|.||:|::.:..|:              |..|..:...:||   ||.:||..||||.||:
  Rat   223 PCEPGCQCRAPMVSVSSER--------------HPLYNRVKTGQIA---NCALPCHNPFFSQDER 270

  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379
            .|...||.|||.|||.||..|::||:||.||||||||||:||||||..|:||||.|....:|::|
  Rat   271 AFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVA 335

  Fly   380 CDG------------------------------------------LLLRESSTGPHSCTLVFLLT 402
            |.|                                          ..:|..:|||..||:||||.
  Rat   336 CSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLV 400

  Fly   403 YFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPIL 467
            |||||||||||||||.|||||||:|||||||..:||||||||||:|:|:|:|||.||:|||||:.
  Rat   401 YFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVA 465

  Fly   468 GICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLM 532
            |||||||.:.|:|:.||||||.:||.|||.||:||||||||||||||||||   ..|..||||||
  Rat   466 GICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGG---PTKTHKLEKLM 527

  Fly   533 IRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGP--GKKPLYSVLMLKYFMALA 595
            ||:|:|:|||||||.:|:.|..||......|.....|||.:...|  .::|.|:|.||||||.|.
  Rat   528 IRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV 592

  Fly   596 VGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSL 660
            ||||||||:||||||||||....|...|                                     
  Rat   593 VGITSGVWVWSGKTLESWRALCTRCCWA------------------------------------- 620

  Fly   661 LATPYTQAGGASVASTSHHHLHHHVLKQPAASHVXHGESGGASTMGGGGGGGSTLGGGTLGHGTA 725
                   :.||:|                                 |.|.|||..|||       
  Rat   621 -------SKGAAV---------------------------------GAGAGGSGPGGG------- 638

  Fly   726 MSSSTVGMGPLPGTLMHGASGGGVGGGNPGNVYGNGNNGVGGQNTAPGSV 775
                    ||.||      .|||.|||. |::|.:.:.|:..::....||
  Rat   639 --------GPGPG------GGGGHGGGG-GSLYSDVSTGLTWRSGTASSV 673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 88/118 (75%)
Frizzled 308..618 CDD:279827 204/353 (58%)
Fzd8NP_001037716.1 CRD_FZ8 31..155 CDD:143570 89/122 (73%)
Palmitate-binding groove. /evidence=ECO:0000250 71..78 6/6 (100%)
Wnt-binding. /evidence=ECO:0000250 95..100 4/4 (100%)
Wnt-binding. /evidence=ECO:0000250 147..152 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..222 17/70 (24%)
PHA03356 <183..219 CDD:177594 10/39 (26%)
Frizzled 264..614 CDD:279827 204/352 (58%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 605..610 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..655 17/46 (37%)
PDZ-binding. /evidence=ECO:0000250 682..684
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 416 1.000 Domainoid score I639
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 639 1.000 Inparanoid score I791
OMA 1 1.010 - - QHG49270
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 1 1.000 - - FOG0003114
OrthoInspector 1 1.000 - - otm45594
orthoMCL 1 0.900 - - OOG6_106776
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X126
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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