DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and Fzd8

DIOPT Version :10

Sequence 1:NP_001401042.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_001037716.1 Gene:Fzd8 / 364754 RGDID:1560525 Length:684 Species:Rattus norvegicus


Alignment Length:765 Identity:355/765 - (46%)
Similarity:430/765 - (56%) Gaps:175/765 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICL 126
            |.|:|||:|:|:|||||.|..||:.||:||||||||||||||||||:||||||||||||||||||
  Rat    33 LACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICL 97

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |||.||||.||||||||::||||:|:||.|.||:||.|:.||..|:||.|||:. :.|:..:...
  Rat    98 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDY-NRTDLTTAAP 161

  Fly   192 S------GGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST-STKPCRGRNSKNCQNPQGEKAS 249
            |      ....|....||||..|..|.......|:...||.| :..|.||..::    |.|..|:
  Rat   162 SPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKAR----PPGGGAA 222

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEK 314
            ..|..|.||:|::.:..|:              |..|..:...:||   ||.:||..||||.||:
  Rat   223 PCEPGCQCRAPMVSVSSER--------------HPLYNRVKTGQIA---NCALPCHNPFFSQDER 270

  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379
            .|...||.|||.|||.||..|::||:||.||||||||||:||||||..|:||||.|....:|::|
  Rat   271 AFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVA 335

  Fly   380 CDG------------------------------------------LLLRESSTGPHSCTLVFLLT 402
            |.|                                          ..:|..:|||..||:||||.
  Rat   336 CSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLV 400

  Fly   403 YFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPIL 467
            |||||||||||||||.|||||||:|||||||..:||||||||||:|:|:|:|||.||:|||||:.
  Rat   401 YFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVA 465

  Fly   468 GICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLM 532
            |||||||.:.|:|:.||||||.:||.|||.||:||||||||||||||||||   ..|..||||||
  Rat   466 GICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGG---PTKTHKLEKLM 527

  Fly   533 IRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGP--GKKPLYSVLMLKYFMALA 595
            ||:|:|:|||||||.:|:.|..||......|.....|||.:...|  .::|.|:|.||||||.|.
  Rat   528 IRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV 592

  Fly   596 VGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSL 660
            ||||||||:||||||||||....|...|                                     
  Rat   593 VGITSGVWVWSGKTLESWRALCTRCCWA------------------------------------- 620

  Fly   661 LATPYTQAGGASVASTSHHHLHHHVLKQPAASHVXHGESGGASTMGGGGGGGSTLGGGTLGHGTA 725
                   :.||:|                                 |.|.|||..|||       
  Rat   621 -------SKGAAV---------------------------------GAGAGGSGPGGG------- 638

  Fly   726 MSSSTVGMGPLPGTLMHGASGGGVGGGNPGNVYGNGNNGVGGQNTAPGSV 775
                    ||.||      .|||.|||. |::|.:.:.|:..::....||
  Rat   639 --------GPGPG------GGGGHGGGG-GSLYSDVSTGLTWRSGTASSV 673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001401042.1 CRD_FZ5_like 63..182 CDD:143565 88/118 (75%)
7tmF_FZD5_FZD8-like 307..618 CDD:320163 205/354 (58%)
TM helix 1 316..341 CDD:320163 14/24 (58%)
TM helix 2 350..371 CDD:320163 15/20 (75%)
TM helix 3 396..422 CDD:320163 22/25 (88%)
TM helix 4 439..455 CDD:320163 11/15 (73%)
TM helix 5 477..506 CDD:320163 19/28 (68%)
TM helix 6 531..558 CDD:320163 17/26 (65%)
TM helix 7 579..604 CDD:320163 17/24 (71%)
Fzd8NP_001037716.1 CRD_FZ8 31..155 CDD:143570 89/122 (73%)
Wnt-binding. /evidence=ECO:0000250 95..100 4/4 (100%)
Wnt-binding. /evidence=ECO:0000250 147..152 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..222 17/70 (24%)
7tmF_FZD8 263..615 CDD:320378 205/354 (58%)
TM helix 1 272..297 CDD:320378 14/24 (58%)
TM helix 2 306..327 CDD:320378 15/20 (75%)
TM helix 3 394..416 CDD:320378 19/21 (90%)
TM helix 4 437..453 CDD:320378 11/15 (73%)
TM helix 5 475..498 CDD:320378 14/22 (64%)
TM helix 6 528..553 CDD:320378 15/24 (63%)
TM helix 7 576..601 CDD:320378 17/24 (71%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 605..610 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..655 17/46 (37%)
PDZ-binding. /evidence=ECO:0000250 682..684
Blue background indicates that the domain is not in the aligned region.

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