DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and Smo

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_795970.3 Gene:Smo / 319757 MGIID:108075 Length:793 Species:Mus musculus


Alignment Length:744 Identity:195/744 - (26%)
Similarity:311/744 - (41%) Gaps:182/744 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNL------- 62
            ||..|:| ||||      .||...|.......|.|.|  .||.:....|||....|.|       
Mouse    16 RLLQLLL-LVLL------GGPGRGAALSGNVTGPGPH--SASGSSRRDVPVTSPPPPLLSHCGRA 71

  Fly    63 -RCEEITIPMCRG--IGYNMTSFPNEMNHETQDEA--------GL-EVHQFWPLVEIKCSPDLKF 115
             .||.:...:|.|  :.|..|:.....:.::|:||        || ...:.|.:::    |    
Mouse    72 AHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ----P---- 128

  Fly   116 FLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMAC--EHLPLHGDPDNLCM 178
            .||::|.|.| |:....|| .|::|:..|..||.:.::..  ||:.:.|  :|.| .|.|:.:  
Mouse   129 LLCAVYMPKC-ENDRVELP-SRTLCQATRGPCAIVERERG--WPDFLRCTPDHFP-EGCPNEV-- 186

  Fly   179 EQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNP 243
                                                                    :|.|  .|.
Mouse   187 --------------------------------------------------------QNIK--FNS 193

  Fly   244 QGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPF 308
            .|:          |.:||:               ...:|..||.:        |..|||.|:.|.
Mouse   194 SGQ----------CEAPLV---------------RTDNPKSWYED--------VEGCGIQCQNPL 225

  Fly   309 FSNDEKDFAGLWIALW---SGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACYFMVAVGYLS 369
            |:..|......:||.:   :|||   ||.||.||:.|.... :||...:.:::||:|:.::|:|:
Mouse   226 FTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLA 287

  Fly   370 RNFLQ--NEEIAC--DGLLL--RESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTW---FLAAG 425
            : |:.  ..||.|  ||.:.  ..:|:...||.::|::.|:..||..:|:|:|::.|   |.|.|
Mouse   288 Q-FMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALG 351

  Fly   426 LKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFV 490
            ..:  :.::..:.||||..|.:|.|.:||:|.::.||||.:.|||:||..|..:...|||||:.:
Mouse   352 TTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGL 414

  Fly   491 YLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLY 555
            .|::|..||:.|.::||.|:|   ...|:.:...|.|:.:.|:|:|||..|......|...|:.|
Mouse   415 VLIVGGYFLIRGVMTLFSIKS---NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFY 476

  Fly   556 EAAYFEDWIKA----LACPCAQVKG-PGKKPL--------YSVLM--LKYFMALAVGITSGVWIW 605
            :.....:|.::    :.|......| |.|||:        .|:|:  :..|.....||....|:|
Mouse   477 DFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVW 541

  Fly   606 SGKTLESWRRFWRRLLG----APDRTGAN----QALIKQRPPIPHPYAGSGMGMPVGSAAGSLLA 662
            :..||..|||.|.||.|    .|.|...:    :|..|:|..:.:|.......|...|..|.:..
Mouse   542 TKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAG 606

  Fly   663 TPY-TQAGGASVASTSHHHLHHHVLKQPA 690
            ..: .....|.|:|....|:...|.::.|
Mouse   607 LAFDLNEPSADVSSAWAQHVTKMVARRGA 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 33/131 (25%)
Frizzled 308..618 CDD:279827 106/337 (31%)
SmoNP_795970.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..61 8/27 (30%)
CRD_SMO 70..200 CDD:143560 38/212 (18%)
Frizzled 225..554 CDD:279827 106/337 (31%)
Interaction with BBS5 and BBS7. /evidence=ECO:0000269|PubMed:22072986 542..573 11/30 (37%)
Interaction with DLG5. /evidence=ECO:0000269|PubMed:25644602 585..597 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D509772at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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