DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz2 and Smo

DIOPT Version :10

Sequence 1:NP_001401042.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_795970.3 Gene:Smo / 319757 MGIID:108075 Length:793 Species:Mus musculus


Alignment Length:744 Identity:195/744 - (26%)
Similarity:311/744 - (41%) Gaps:182/744 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNL------- 62
            ||..|:| ||||      .||...|.......|.|.|  .||.:....|||....|.|       
Mouse    16 RLLQLLL-LVLL------GGPGRGAALSGNVTGPGPH--SASGSSRRDVPVTSPPPPLLSHCGRA 71

  Fly    63 -RCEEITIPMCRG--IGYNMTSFPNEMNHETQDEA--------GL-EVHQFWPLVEIKCSPDLKF 115
             .||.:...:|.|  :.|..|:.....:.::|:||        || ...:.|.:::    |    
Mouse    72 AHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ----P---- 128

  Fly   116 FLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMAC--EHLPLHGDPDNLCM 178
            .||::|.|.| |:....|| .|::|:..|..||.:.::..  ||:.:.|  :|.| .|.|:.:  
Mouse   129 LLCAVYMPKC-ENDRVELP-SRTLCQATRGPCAIVERERG--WPDFLRCTPDHFP-EGCPNEV-- 186

  Fly   179 EQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNP 243
                                                                    :|.|  .|.
Mouse   187 --------------------------------------------------------QNIK--FNS 193

  Fly   244 QGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPF 308
            .|:          |.:||:               ...:|..||.:        |..|||.|:.|.
Mouse   194 SGQ----------CEAPLV---------------RTDNPKSWYED--------VEGCGIQCQNPL 225

  Fly   309 FSNDEKDFAGLWIALW---SGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACYFMVAVGYLS 369
            |:..|......:||.:   :|||   ||.||.||:.|.... :||...:.:::||:|:.::|:|:
Mouse   226 FTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLA 287

  Fly   370 RNFLQ--NEEIAC--DGLLL--RESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTW---FLAAG 425
            : |:.  ..||.|  ||.:.  ..:|:...||.::|::.|:..||..:|:|:|::.|   |.|.|
Mouse   288 Q-FMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALG 351

  Fly   426 LKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFV 490
            ..:  :.::..:.||||..|.:|.|.:||:|.::.||||.:.|||:||..|..:...|||||:.:
Mouse   352 TTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGL 414

  Fly   491 YLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLY 555
            .|::|..||:.|.::||.|:|   ...|:.:...|.|:.:.|:|:|||..|......|...|:.|
Mouse   415 VLIVGGYFLIRGVMTLFSIKS---NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFY 476

  Fly   556 EAAYFEDWIKA----LACPCAQVKG-PGKKPL--------YSVLM--LKYFMALAVGITSGVWIW 605
            :.....:|.::    :.|......| |.|||:        .|:|:  :..|.....||....|:|
Mouse   477 DFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVW 541

  Fly   606 SGKTLESWRRFWRRLLG----APDRTGAN----QALIKQRPPIPHPYAGSGMGMPVGSAAGSLLA 662
            :..||..|||.|.||.|    .|.|...:    :|..|:|..:.:|.......|...|..|.:..
Mouse   542 TKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAG 606

  Fly   663 TPY-TQAGGASVASTSHHHLHHHVLKQPA 690
            ..: .....|.|:|....|:...|.::.|
Mouse   607 LAFDLNEPSADVSSAWAQHVTKMVARRGA 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001401042.1 CRD_FZ5_like 63..182 CDD:143565 33/131 (25%)
7tmF_FZD5_FZD8-like 307..618 CDD:320163 107/338 (32%)
TM helix 1 316..341 CDD:320163 11/27 (41%)
TM helix 2 350..371 CDD:320163 5/20 (25%)
TM helix 3 396..422 CDD:320163 8/28 (29%)
TM helix 4 439..455 CDD:320163 8/15 (53%)
TM helix 5 477..506 CDD:320163 10/28 (36%)
TM helix 6 531..558 CDD:320163 9/26 (35%)
TM helix 7 579..604 CDD:320163 8/34 (24%)
SmoNP_795970.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..61 8/27 (30%)
CRD_SMO 70..200 CDD:143560 38/212 (18%)
7tmF_SMO_homolog 224..554 CDD:320158 107/338 (32%)
TM helix 1 233..258 CDD:320158 11/27 (41%)
TM helix 2 268..289 CDD:320158 5/21 (24%)
TM helix 3 319..345 CDD:320158 8/25 (32%)
TM helix 4 363..379 CDD:320158 8/15 (53%)
TM helix 5 401..430 CDD:320158 10/28 (36%)
TM helix 6 452..479 CDD:320158 9/26 (35%)
TM helix 7 515..540 CDD:320158 5/24 (21%)
Interaction with BBS5 and BBS7. /evidence=ECO:0000269|PubMed:22072986 542..573 11/30 (37%)
Required for interaction with PRKACA. /evidence=ECO:0000269|PubMed:33886552 574..657 13/62 (21%)
Interaction with DLG5. /evidence=ECO:0000269|PubMed:25644602 585..597 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..703
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.