DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fz4

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	183/751 - (24%)
Similarity:	280/751 - (37%)	Gaps:	226/751 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PKDPNLR-CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSM 120
            |:.|..| ||.|.|.|||.||||.||.||.:.:|.|.:....:..|.||:|..||..||.|||:.
  Fly    38 PEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAA 102

  Fly   121 YTPICLEDYHKPLPV-----CRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQ 180
            |.|:|.    ...||     |||:||..|..|.|::|.:.|.||..:.|:..|...:.:.:|||
  Fly   103 YVPMCT----PKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCME- 162

  Fly   181 PSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQG 245
                              |.|.....:::|...|..|.|..|..|......|.|
  Fly   163 ------------------GPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSG----------- 198

  Fly   246 EKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-FF 309
                              |.|.                |.|:     |:.....|...|:.. .|
  Fly   199 ------------------LAKS----------------HLYV-----RLPRSGRCAPLCEADILF 224

  Fly   310 SNDEKDFAGLWIALWS----GLCFCSTLMTLTTFIIDTERFKYPE-----RPIVFLSACYFMVAV 365
            :..||..|.:|::.|:    ||...:|:..|.:   |..|....:     .|:::   |:.||.:
  Fly   225 TPAEKHLAEIWVSTWAYAALGLALVATVCLLAS---DGSRLASAKWSRLLSPLIW---CHNMVTL 283

  Fly   366 GYLSRNFLQNEEIAC-------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLA 423
            |:..|..:.....||       :..||........||..|||:.|:||||:..||.:|...|
  Fly   284 GWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGW--- 345

  Fly   424 AGLKWGNEAITKHS---------------------------------QYFHLAAWLIPTVQSVAV 455
                  :..|.:||                                 .:....||.:|..|:.||
  Fly   346 ------HRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAV 404

  Fly   456 LLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVG 520
            ::...||.|.:||.|:|||.:...|:..|..|:|.|.:.|:..|::|::...|.:.:::....:.
  Fly   405 IVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALS 469

  Fly   521 AGVKADKLEKLMIR----IGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKP 581
            .   ..:|::|...    ||||..:|.:...:::...:||.|..:.|:.:         |....|
  Fly   470 V---QQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGS---------GDTNTP 522

  Fly   582 LYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAG 646
            |:..| |:.||.|.:||....|: .|.::.:..:          |..:|..::|      |..||
  Fly   523 LWPFL-LRAFMELMLGICCFAWV-LGPSISTLYK----------RQVSNGKMVK------HTSAG 569

  Fly   647 SGMGMPVG--SAAGS----------------------LLATPY-------------TQAGGASVA 674
            :..|...|  |:.||                      |..:||             .|....|:.
  Fly   570 AATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSISLNQMSNYSLG 634

  Fly   675 STSHH------HLHHHVLKQ-----PAASHVXHGES 699
            .:.||      |.|||..:|     |..:|..|..|
  Fly   635 RSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTS 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	51/124 (41%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	86/362 (24%)
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	53/148 (36%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	84/348 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850