DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fz3

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	155/583 - (26%)
Similarity:	242/583 - (41%)	Gaps:	104/583 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 NHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGC---A 148
            ::::.||.| ::.:..||:|..||...:|.|||...|:|..|..:|:..|:.:||..|..|   |
  Fly   129 DYKSDDEKG-QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENA 192

  Fly   149 P--IMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQG 211
            |  :|:.    ||..:.|:.|| ..:...|||:.|... |..|||..|...:||.......:...
  Fly   193 PPELMEL----WPSFLNCDGLP-QPEKHELCMQIPQEV-AVPGGSPSGPPTTGSPGVEDHPQTYR 251

  Fly   212 GSGSGGSGAGGSSGSTSTKPCRGRNSKNC-QNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQ 275
            ...||.|.....:|..            | ||..|...:.:||
  Fly   252 FWKSGASPTSDLAGVL------------CPQNFSGSPFNPEEC---------------------- 282

  Fly   276 MPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFI 340
                                 ||.|.   :..|.::.:|..:...|...|.:||..||..|.||.
  Fly   283 ---------------------VPQCQ---RDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFW 323

  Fly   341 IDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNE----EIACDGLLLRESSTGPHSCTLVFLL 401
            .:..||.|||||::||..||.:.:|.||.|....|:    ::.....|:|........|...::.
  Fly   324 AEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLTPPCLASYIT 388

  Fly   402 TYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPI 466
            |.:..:.::.||:|.:..::|::..||.:||:.|.|..||:.||:.|....:|.|||..|....:
  Fly   389 TSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSEL 453

  Fly   467 LGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKL 531
            .|:||...        ||..|..|.|::|..|      :|...||::..|..:...:...:..::
  Fly   454 TGMCYAPG--------FVELPALVLLLLGLYF------TLRASRSLLSLQQQLQPTLAHHRFGQI 504

  Fly   532 MIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACP--CAQVKGPGKKPLYS-VLMLKYFMA 593
            ..|..:||:||..|.|..:...|.|.  :.|.:.:.:.|  |.     ...||.: ..:::.|..
  Fly   505 RKRFVLFSLLYFAPTTAGVVAALCER--YADSVPSCSTPDDCL-----SPTPLSAWPALVRIFFQ 562

  Fly   594 LAVGITSGVWIWSGKTLESWRRFWRRL--LGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVG 654
            |..|..:|:|:||.||.||:|   .||  .|.|..:..||:......|..|.|......:|.|
  Fly   563 LVGGTLTGLWVWSRKTCESYR---NRLGASGTPTSSLMNQSKAAGALPKKHLYTSGKSMLPTG 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	32/99 (32%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	91/316 (29%)
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	30/90 (33%)
		Frizzled	291..584	CDD:279827	91/316 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48983at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850