DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd2

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_571215.1	Gene:	fzd2 / 30370	ZFINID:	ZDB-GENE-990415-224	Length:	550	Species:	Danio rerio

Alignment Length:	639	Identity:	271/639 - (42%)
Similarity:	367/639 - (57%)	Gaps:	134/639 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGY 77
            |.|||..|......|..|:|:           |.|..|:            |:.||||:|..|.|
Zfish    11 LALLLPCCFVASGQHQGDNGI-----------AVPDHGF------------CQPITIPLCTDIAY 52

  Fly    78 NMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVCRSVC 140
            |.|..||.:.|..|::||||||||:|||:::|||:|||||||||.|:|  ||   |.:|.|||:|
Zfish    53 NQTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLE---KAIPPCRSIC 114

  Fly   141 ERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSG 205
            |||:.||..:|.::.|:|||.:.|||.|:.|| .::|:
Zfish   115 ERAKQGCEVLMNKFGFQWPEALRCEHFPVLGD-GHICV--------------------------- 151

  Fly   206 GKRKQGGSGSGGSGAGGSSGSTST-----KPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLG 265
                            |.:.|.:|     .|..|       .|..:..|..:....|.|.|
Zfish   152 ----------------GQNDSMATVSPVHMPIPG-------TPSVQLYSTPDKPFRCPSTL---- 189

  Fly   266 KEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-------FFSNDEKDFAGLWIAL 323
                     ::|.       |::   .:..|.|:||.||:..       ||::.|.:||.:||.:
Zfish   190 ---------KVPA-------YLS---YKFLGEPDCGAPCESSRTHRAYMFFTDQEIEFARIWILI 235

  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRES 388
            ||.||..|||.|:||:|:|.:|||||||||:|||.||.||::.|::..|| .:::.|:.....:|
Zfish   236 WSSLCCASTLFTVTTYIVDMQRFKYPERPIIFLSGCYTMVSIAYIAGYFL-GDKVVCNESFFPDS 299

  Fly   389 ------STGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLI 447
                  .|....||::|::.|||.|||||||||||.|||||||:|||:|||..:|||||||||.:
Zfish   300 YKTIVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAV 364

  Fly   448 PTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSV 512
            |.|:::::|.:..:|||.:.|:|:||..|.|.|:.|:|||||:||.|||:||:||||||||||::
Zfish   365 PAVKTISILAMGQIDGDVLSGVCFVGLNNSDALRGFILAPLFLYLFIGTSFLLAGFVSLFRIRTI 429

  Fly   513 IKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALAC 569
            :|..     |.|.:|||:||:|||:|||||||||||||.|:.||.|:.:.|        .|:||.
Zfish   430 MKHD-----GTKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRQQWEKSWISMNCKSLAI 489

  Fly   570 PCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            ||.....|...|.::|.|:||.|.|.||||||.||||||||.||::|:.||..|
Zfish   490 PCPMQPAPHMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWQKFYVRLTSA 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	64/120 (53%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	175/323 (54%)
fzd2	NP_571215.1	CRD_FZ1_like	37..154	CDD:143567	66/175 (38%)
		7tmF_FZD2	219..548	CDD:320373	178/331 (54%)
		TM helix 1	228..253	CDD:320373	14/24 (58%)
		TM helix 2	262..283	CDD:320373	12/20 (60%)
		TM helix 3	313..339	CDD:320373	18/25 (72%)
		TM helix 4	356..372	CDD:320373	9/15 (60%)
		TM helix 5	394..423	CDD:320373	19/28 (68%)
		TM helix 6	443..470	CDD:320373	21/26 (81%)
		TM helix 7	499..524	CDD:320373	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810