Protein Alignment fz2 and fzd5

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_571209.2
• Gene: fzd5 / 30364
• ZFINID: ZDB-GENE-990415-218
• Length: 592
• Species: Danio rerio
• Alignment Length: 685
• Identity: 345/685 - (50%)
• Similarity: 416/685 - (60%)
• Gaps: 130/685 - (18%)

  Fly    32 GMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGL 96
            ||..:|...|.|......|.| ....||  :.||.||:|||:|||||.|..||:.||:.|||.||
Zfish    16 GMHLVGFWLHVLLLFQLSGLG-DSASKD--IVCEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGL 77

  Fly    97 EVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPER 161
            |||||||||.|.|||||.||||||||||||:||.||||.||||||||:.||:|:|.||.||||||
Zfish    78 EVHQFWPLVRIHCSPDLLFFLCSMYTPICLQDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPER 142

  Fly   162 MACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGS 226
            |:||.||:.||.|.|||::                                          :|..
Zfish   143 MSCEQLPMLGDTDRLCMDR------------------------------------------NSSE 165

  Fly   227 TST------KPCRGRNSKNCQNPQG--------EKASGKEC--SCSCRSPLIFLGKEQLLQQQSQ 275
            |:|      ||          .|:|        :.|..::|  .|.||.||:.:.||.
Zfish   166 TTTLSPPFPKP----------TPKGTPRHRATAKSAPPQKCDRECHCRGPLVPIKKEA------- 213

  Fly   276 MPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFI 340
                 ||.|..:|     ...:|||.:||..|:||.||:.|...||.|||.|||.||..|:.||:
Zfish   214 -----HPLHNRVN-----TGSLPNCALPCHQPYFSQDERTFTTFWIGLWSVLCFVSTFTTVATFL 268

  Fly   341 IDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGL-----LLRESSTGPHSCTLVFL 400
            ||.||||||||||:||:|||..|::||:.|....:|.:||:|.     :|.: :|||..||||||
Zfish   269 IDMERFKYPERPIIFLAACYLFVSLGYIVRLLAGHERVACEGTGDQQHILYD-TTGPALCTLVFL 332

  Fly   401 LTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDP 465
            |.||||||||||||:||||||||||:|||||||..:||||||||||:|:|:|:|||.||:|||||
Zfish   333 LIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDP 397

  Fly   466 ILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEK 530
            :.|||||||.:.:.|:.||||||.|||..|:.||:|||||||||||||||     .|.|.|||||
Zfish   398 VAGICYVGNQSLEGLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKQ-----GGTKTDKLEK 457

  Fly   531 LMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPC-AQVKGPGKKPLYSVLMLKYFMAL 594
            ||||||:|:||||||||||:.|.:||..|...|.:||||.| ::.:..|..|.|:|.||||||.|
Zfish   458 LMIRIGLFTVLYTVPATIVVACLVYEQHYRPSWERALACSCPSERQRLGMGPDYAVFMLKYFMCL 522

  Fly   595 AVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGS 659
            .|||||||||||||||||||||..|.:  |.||        ::||:.            .|:..|
Zfish   523 VVGITSGVWIWSGKTLESWRRFIARYV--PCRT--------RKPPVS------------ASSMYS 565

  Fly   660 LLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV 694
            ..:|..|...|.:...|.|        |...:|||
Zfish   566 EASTALTARAGTAPTGTYH--------KSAPSSHV 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	86/118 (73%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	208/316 (66%)
		TM helix 1	316..341	CDD:320163	14/24 (58%)
		TM helix 2	350..371	CDD:320163	12/20 (60%)
		TM helix 3	396..422	CDD:320163	23/25 (92%)
		TM helix 4	439..455	CDD:320163	11/15 (73%)
		TM helix 5	477..506	CDD:320163	17/28 (61%)
		TM helix 6	531..558	CDD:320163	20/26 (77%)
		TM helix 7	579..604	CDD:320163	17/24 (71%)
fzd5	NP_571209.2	CRD_FZ5_like	44..163	CDD:143565	86/160 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..192		7/39 (18%)
		7tmF_FZD5	235..546	CDD:320377	208/316 (66%)
		TM helix 1	244..269	CDD:320377	14/24 (58%)
		TM helix 2	278..299	CDD:320377	12/20 (60%)
		TM helix 3	328..354	CDD:320377	23/25 (92%)
		TM helix 4	371..387	CDD:320377	11/15 (73%)
		TM helix 5	409..438	CDD:320377	17/28 (61%)
		TM helix 6	458..485	CDD:320377	20/26 (77%)
		TM helix 7	507..532	CDD:320377	17/24 (71%)