Protein Alignment fz2 and fzd4

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001292398.1
• Gene: fzd4 / 30363
• ZFINID: ZDB-GENE-990415-217
• Length: 523
• Species: Danio rerio
• Alignment Length: 584
• Identity: 230/584 - (39%)
• Similarity: 317/584 - (54%)
• Gaps: 117/584 - (20%)

  Fly    59 DPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTP 123
            :..:.|:.|.|.||:.:|||:|..||.:.:..|.:|.|::..|.||::..||..|||||||:|.|
Zfish    24 EEEMTCDPIRISMCQDLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVP 88

  Fly   124 ICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGS 188
            :|.|....|:..|.|:|...:..|.|::|::.|.|||.:.|...|...|.:::|||.|
Zfish    89 MCTEKVPIPIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNCSLFPPTNDQNHMCMEGP------- 146

  Fly   189 GGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST--STKPCRGRNSKNCQNPQGEKASGK 251
                                             |.....  :.:|..         ||.|
Zfish   147 ---------------------------------GDEDPPFHAVRPVA---------PQEE----- 164

  Fly   252 ECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEK 314
            ||..      :..|.||              :.|     |:|..   :|.:.|  ....:....|
Zfish   165 ECIA------LGAGVEQ--------------YAW-----VKRSG---SCSLQCGYDTGLYRRQAK 201

  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379
            .|..:|:|:|:.|||.||..|:.||::|:.||.||||||:|||.|..:.:|.::.|..:..|.|:
Zfish   202 VFTDVWMAVWAVLCFISTTFTVLTFLVDSSRFSYPERPIIFLSMCCNIYSVAFIVRLTVGRERIS 266

  Fly   380 CD------GLLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKH 436
            ||      .:|::|  .:||   |.:|||||||||||||||||||:.|||||||||||:|||..|
Zfish   267 CDLEEAAVPVLVQEGLKNTG---CAIVFLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMH 328

  Fly   437 SQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMA 501
            |.|||:|||.||.|:::.:|::..||.|.:.|:|||||.|.|.|..||:||||.||||||.|:.|
Zfish   329 SSYFHIAAWAIPAVKTIVILIMRLVDADDLAGMCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAA 393

  Fly   502 GFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKA 566
            |.|:||:|||.:::.     |.|.||||:||::||:||||||||||.||.||.||   ..:|
Zfish   394 GLVALFKIRSNLQKD-----GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--- 447

  Fly   567 LACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGAN 630
                 |..:...:....:..||:.||:|.||||||:|:||.|||.:|:|...||:    .||.|
Zfish   448 -----ADFRQTARDSYMAAEMLRIFMSLLVGITSGMWVWSAKTLHTWQRCSHRLV----HTGRN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	47/118 (40%)
		Frizzled	308..618	CDD:279827	162/317 (51%)
fzd4	NP_001292398.1	CRD_FZ4	26..150	CDD:143557	49/163 (30%)
		Frizzled	195..492	CDD:279827	161/315 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920