DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and Corin

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	76/332 - (22%)
Similarity:	115/332 - (34%)	Gaps:	115/332 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SPAPG--------------YGVPVIPKDPNL----RCEEITIPMCRGIGYNMTSFPNEMNHETQD 92
            :|.||              .|..:...|.:|    .||.||:.:|..:.||:|.:||.:.|.||.
  Rat   485 TPCPGGDRGCLDSSCVESCAGSSLCDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQK 549

  Fly    93 EAGL--EVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYS 155
            ||.:  |...|..||:..|...|.||.|::..|.|..:..:.:|.||.:||.::..|..::....
  Rat   550 EASISWESALFPALVQTNCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVG 614

  Fly   156 FEWPERMACEHLPLHGDPDNLCM------EQ--PSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGG 212
            .:|||...|...|.....:..|:      |:  ||:.:..||....||
  Rat   615 LQWPEDTDCSQFPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGS----------------- 662

  Fly   213 SGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMP 277
                             :.|.|:  .:|.:...|:      :|.|        ||:.|
  Rat   663 -----------------RRCDGQ--ADCDDDSDEE------NCGC--------KERDL------- 687

  Fly   278 MMHHPHHWYMNLTVQRIA------GVPNCGIP-----CKGPFFSNDEKDFAG-------LWIALW 324
                   |...|..|.:.      |.|:|...     |.  |..:||.:.|.       ||...|
  Rat   688 -------WECPLNKQCLKHTLICDGFPDCSDSMDEKNCS--FCQDDELECANHECVPRDLWCDGW 743

  Fly   325 SGLCFCS 331
            :.   ||
  Rat   744 TD---CS 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	39/128 (30%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	9/31 (29%)
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579	38/119 (32%)
		Ldl_recept_a	646..680	CDD:395011	10/75 (13%)
		LDLa	<693..718	CDD:238060	4/24 (17%)
		LDLa	721..755	CDD:238060	8/30 (27%)
		SRCR_2	779..859	CDD:413346
		Tryp_SPc	867..1098	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810