DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and Fzd6

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001124008.1	Gene:	Fzd6 / 282581	RGDID:	628816	Length:	710	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	234/800 - (29%)
Similarity:	335/800 - (41%)	Gaps:	185/800 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LDASP--APGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLV 105
            ::|||  :....:|:|.......||.||:|.|..:.||||.|||.|.|..|..|.:|:..|.||.
  Rat     1 MEASPFLSACILLPLIRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQGIAAVEMEHFLPLA 65

  Fly   106 EIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHL--- 167
            .::|||:::.|||..:.|.|.|......| ||.:||:..|.|..:|..:...|||.:.|..|
  Rat    66 NLECSPNIEMFLCQAFVPTCTEQIDVVSP-CRKLCEKILSDCQKLMDTFGIRWPEELECHRLPYC 129

  Fly   168 ----PLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTS 228
                |:..||         :||
  Rat   130 DGAVPVTSDP---------HTE------------------------------------------- 142

  Fly   229 TKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQR 293
               ..|...|..|.|       ::....|...|...|.:.                       .|
  Rat   143 ---LFGPQKKTDQVP-------RDIGFWCPKHLRTSGDQG-----------------------YR 174

  Fly   294 IAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSA 358
            ..|:..|..||...:|.:||.|||..:|.:.|..|.|:||.|..||:||..||:||||||::.|.
  Rat   175 FLGIDQCAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSV 239

  Fly   359 CYFMVAVGYLSRNFLQNEEIAC----DGLLLRES---STGPHSCTLVFLLTYFFGMASSIWWVIL 416
            ||.:|::.|.. .||.....||    :.|.|..:   .:...:|::||:..|||.||.::|||||
  Rat   240 CYSIVSLMYFV-GFLLGNSTACNKADEKLELGNTVVLGSKNKACSVVFMFLYFFTMAGTVWWVIL 303

  Fly   417 SFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLK 481
            :.|||||||.||..|||.:.:.:||..||.:|...:|.:|.::.|:||.|.|:|:||..:.|..:
  Rat   304 TITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASR 368

  Fly   482 TFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPA 546
            .|||.||.:.:.:|.:.|:||.:||..:|.||:..|.     ..:||:|.|||||:||.||.||.
  Rat   369 YFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGR-----NQEKLKKFMIRIGVFSGLYLVPL 428

  Fly   547 TIVIGCYLY--------EAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVW 603
            ..::|||:|        |..:|.|.......||.....|..:|..::.|:||.|.|.|||::..|
  Rat   429 VTLLGCYVYELVNRVTWEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFW 493

  Fly   604 IWSGKTLESWRRFWRRLLGAPDRTGANQAL-----------IKQRPPIPHPYAGSGMGMPVGSAA 657
            :.|.||...|..|.:|.......:.:.:.|           .|.|....|...||.....:..:.
  Rat   494 VGSKKTCTEWAGFCKRNRKRDPISESRRVLQESCEFFLKHNSKVRHKKKHGKPGSHKLKVISKSM 558

  Fly   658 GSLLATPYTQAGGASVASTSHHHLHH----HVLKQPAASHVXHGESGGASTMGGGG--------- 709
            |:..... |..|.::||...|.:|..    .|...|.|| : .|.:..|:|....|
  Rat   559 GTSTGVT-TDHGTSAVAIADHDYLGQETSAEVQTSPEAS-LKEGRADRANTPRAKGPDCGEPAST 621

  Fly   710 -GGGSTLGGGTLGH----GTAMSSSTVGMGP----------LPGT-------------------- 739
             ...|...|..:..    |:....|:|..|.          :|||
  Rat   622 AASNSKFSGDQIDRKSRAGSVKEKSSVSEGAPSEGRVSPKGVPGTGLMECTLQIPSSPEPNSLKG 686

  Fly   740 ----LMHGASG----GGVGG 751
                |:..|||    .|.||
  Rat   687 STSLLVRSASGTRKEQGAGG 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	46/125 (37%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	131/324 (40%)
Fzd6	NP_001124008.1	CRD_FZ6	20..146	CDD:143559	48/181 (27%)
		7tmF_FZD6	188..508	CDD:320160	131/325 (40%)
		TM helix 1	198..222	CDD:320160	10/23 (43%)
		TM helix 2	231..252	CDD:320160	9/21 (43%)
		TM helix 3	283..305	CDD:320160	12/21 (57%)
		TM helix 4	326..342	CDD:320160	6/15 (40%)
		TM helix 5	364..387	CDD:320160	7/22 (32%)
		TM helix 6	418..440	CDD:320160	11/21 (52%)
		TM helix 7	469..494	CDD:320160	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810