| Sequence 1: | NP_001262037.1 | Gene: | fz2 / 40090 | FlyBaseID: | FBgn0016797 | Length: | 806 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_695217.1 | Gene: | Fzd9 / 266608 | RGDID: | 628817 | Length: | 592 | Species: | Rattus norvegicus |
| Alignment Length: | 615 | Identity: | 252/615 - (40%) |
|---|---|---|---|
| Similarity: | 341/615 - (55%) | Gaps: | 110/615 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 36 MGMGGHGLD---------ASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQ 91
Fly 92 DEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSF 156
Fly 157 EWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAG 221
Fly 222 GSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWY 286
Fly 287 MNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPER 351
Fly 352 PIVFLSACYFMVAVGYLSRNFLQNEEIACD---GLL--LRE--SSTGPHSCTLVFLLTYFFGMAS 409
Fly 410 SIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGN 474
Fly 475 LNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFS 539
Fly 540 VLYTVPATIVIGCYLYEAAYFEDW-IKALACPCAQVKGPGKK----------PLYSVLMLKYFMA 593
Fly 594 LAVGITSGVWIWSGKTLESWRRFWRRLLGA 623 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz2 | NP_001262037.1 | CRD_FZ5_like | 63..182 | CDD:143565 | 58/118 (49%) |
| Frizzled | 308..618 | CDD:279827 | 163/327 (50%) | ||
| Fzd9 | NP_695217.1 | CRD_FZ9 | 36..162 | CDD:143572 | 63/142 (44%) |
| Required for Wnt-activated receptor activity. /evidence=ECO:0000269|PubMed:12138115 | 59..173 | 50/116 (43%) | |||
| 7tmF_FZD9 | 222..543 | CDD:320164 | 163/328 (50%) | ||
| TM helix 1 | 232..256 | CDD:320164 | 13/23 (57%) | ||
| TM helix 2 | 265..286 | CDD:320164 | 10/20 (50%) | ||
| TM helix 3 | 315..337 | CDD:320164 | 17/21 (81%) | ||
| TM helix 4 | 358..374 | CDD:320164 | 7/15 (47%) | ||
| TM helix 5 | 396..419 | CDD:320164 | 13/22 (59%) | ||
| TM helix 6 | 450..472 | CDD:320164 | 16/21 (76%) | ||
| TM helix 7 | 504..529 | CDD:320164 | 15/24 (63%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 533..538 | 2/4 (50%) | |||
| Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269|PubMed:12138115 | 555..592 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 5 | 4.820 | |||||