Protein Alignment fz2 and Fzd9

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_695217.1
• Gene: Fzd9 / 266608
• RGDID: 628817
• Length: 592
• Species: Rattus norvegicus
• Alignment Length: 615
• Identity: 252/615 - (40%)
• Similarity: 341/615 - (55%)
• Gaps: 110/615 - (17%)

  Fly    36 MGMGGHGLD---------ASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQ 91
            :..||..|:         ..|||              |:.:.||||||||||:|..||.:.|.:|
  Rat    17 LATGGAALEIGRFDPERGRGPAP--------------CQAMEIPMCRGIGYNLTRMPNLLGHTSQ 67

  Fly    92 DEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSF 156
            .||..::.:|.|||:..|...|:|||||:|.|:|.:....|:|.||.:||:||..|||||:|::|
  Rat    68 GEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNF 132

  Fly   157 EWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAG 221
            .||:.:.|..||...||..||||.|   |..:.|.:....|.|....:....:..|..:.|.|:|
  Rat   133 GWPDSLDCARLPTRNDPHALCMEAP---ENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGPGSG 194

  Fly   222 GSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWY 286
            |:                |.||  ||....|.|.||
  Rat   195 GT----------------CDNP--EKFQYVEKSRSC----------------------------- 212

  Fly   287 MNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPER 351
                      .|.|| |....|:|..:||||.:|:|:||.|||.||..|:.||:::..||:||||
  Rat   213 ----------APRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPER 266

  Fly   352 PIVFLSACYFMVAVGYLSRNFLQNEEIACD---GLL--LRE--SSTGPHSCTLVFLLTYFFGMAS 409
            ||:|||.||.:.::.:|.|.....:.:|||   |.|  ::|  .:||   |||||||.|:|||||
  Rat   267 PIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMAS 328

  Fly   410 SIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGN 474
            |:|||:|:.|||||||.|||:|||..|..|||:|||.:|.::::.||.|..|.||.:.|:|||.:
  Rat   329 SLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVVLTLRKVAGDELTGLCYVAS 393

  Fly   475 LNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFS 539
            ::|..|..|||.||..|||:||:||:.|||:||.||.::|.     .|...:||||||::||:||
  Rat   394 MDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFS 453

  Fly   540 VLYTVPATIVIGCYLYEAAYFEDW-IKALACPCAQVKGPGKK----------PLYSVLMLKYFMA 593
            :|||||||.||.||:||....:.| ::|...||.....||.:          |..:|.|||.||:
  Rat   454 ILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAAVPGGRRDCSLPGGSVPTVAVFMLKIFMS 518

  Fly   594 LAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            |.||||||||:||.||.::|:....|.:.|
  Rat   519 LVVGITSGVWVWSSKTFQTWQSLCYRKMAA 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	58/118 (49%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	163/328 (50%)
		TM helix 1	316..341	CDD:320163	14/24 (58%)
		TM helix 2	350..371	CDD:320163	10/20 (50%)
		TM helix 3	396..422	CDD:320163	19/25 (76%)
		TM helix 4	439..455	CDD:320163	7/15 (47%)
		TM helix 5	477..506	CDD:320163	17/28 (61%)
		TM helix 6	531..558	CDD:320163	19/26 (73%)
		TM helix 7	579..604	CDD:320163	15/34 (44%)
Fzd9	NP_695217.1	CRD_FZ9	36..162	CDD:143572	63/142 (44%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000269|PubMed:12138115	59..173		50/116 (43%)
		7tmF_FZD9	222..543	CDD:320164	163/328 (50%)
		TM helix 1	231..256	CDD:320164	14/24 (58%)
		TM helix 2	265..286	CDD:320164	10/20 (50%)
		TM helix 3	315..341	CDD:320164	19/25 (76%)
		TM helix 4	358..374	CDD:320164	7/15 (47%)
		TM helix 5	396..426	CDD:320164	17/29 (59%)
		TM helix 6	445..472	CDD:320164	19/26 (73%)
		TM helix 7	504..529	CDD:320164	15/24 (63%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	533..538		2/4 (50%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269|PubMed:12138115	555..592