DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and FZD2

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_001457.1 Gene:FZD2 / 2535 HGNCID:4040 Length:565 Species:Homo sapiens


Alignment Length:639 Identity:280/639 - (43%)
Similarity:369/639 - (57%) Gaps:120/639 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCR 73
            |:|.|:||    .|.||  :..||..|:.:..||.                    |:.|:||:|.
Human    10 LLLPLLLL----PAAGP--AQFHGEKGISIPDHGF--------------------CQPISIPLCT 48

  Fly    74 GIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVC 136
            .|.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|  ||   :.:|.|
Human    49 DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLE---QAIPPC 110

  Fly   137 RSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSG 201
            ||:|||||.||..:|.::.|:||||:.|||.|.|| .:.:|:.| :::|.|:......:...|..
Human   111 RSICERARQGCEALMNKFGFQWPERLRCEHFPRHG-AEQICVGQ-NHSEDGAPALLTTAPPPGLQ 173

  Fly   202 SGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGK 266
            .|:||.       .||.|.||:....:|                                     
Human   174 PGAGGT-------PGGPGGGGAPPRYAT------------------------------------- 194

  Fly   267 EQLLQQQSQMPMMHHPHHWYMNLTV-----QRIAGVPNCGIPCK------GPFFSNDEKDFAGLW 320
                        :.||.|....|.|     .:..|..:|..||:      ..|||.:|..||.||
Human   195 ------------LEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLW 247

  Fly   321 IALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC----- 380
            |..||.||..||..|:||:::|.:||:||||||:|||.||.||:|.|:: .|:..|.:.|     
Human   248 ILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIA-GFVLQERVVCNERFS 311

  Fly   381 -DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAA 444
             ||.......|....||::|::.|||.|||||||||||.|||||||:|||:|||..:||||||||
Human   312 EDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAA 376

  Fly   445 WLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRI 509
            |.:|.|:::.:|.:..:|||.:.|:|:||..:.|.|:.||||||||||.|||:||:|||||||||
Human   377 WAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRI 441

  Fly   510 RSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKA 566
            |:::|..     |.|.:|||:||:|||:|||||||||||||.||.||.|:.|.|        .|:
Human   442 RTIMKHD-----GTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKS 501

  Fly   567 LACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            ||.||.....|...|.::|.|:||.|.|.||||||.||||||||.|||:|:.||
Human   502 LAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 64/120 (53%)
Frizzled 308..618 CDD:279827 180/323 (56%)
FZD2NP_001457.1 CRD_FZ2 35..161 CDD:143573 68/150 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..189 9/35 (26%)
7tmF_FZD2 234..563 CDD:320373 182/328 (55%)
TM helix 1 244..268 CDD:320373 13/23 (57%)
TM helix 2 277..298 CDD:320373 13/21 (62%)
TM helix 3 328..350 CDD:320373 15/21 (71%)
TM helix 4 371..387 CDD:320373 9/15 (60%)
TM helix 5 409..432 CDD:320373 16/22 (73%)
TM helix 6 463..485 CDD:320373 18/21 (86%)
TM helix 7 514..539 CDD:320373 13/24 (54%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 543..548 3/4 (75%)
PDZ-binding 563..565
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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