Protein Alignment fz2 and FZD2

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001457.1
• Gene: FZD2 / 2535
• HGNCID: 4040
• Length: 565
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 280/639 - (43%)
• Similarity: 369/639 - (57%)
• Gaps: 120/639 - (18%)

  Fly     9 LILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCR 73
            |:|.|:||    .|.||  :..||..|:.:..||.                    |:.|:||:|.
Human    10 LLLPLLLL----PAAGP--AQFHGEKGISIPDHGF--------------------CQPISIPLCT 48

  Fly    74 GIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVC 136
            .|.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|  ||   :.:|.|
Human    49 DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLE---QAIPPC 110

  Fly   137 RSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSG 201
            ||:|||||.||..:|.::.|:||||:.|||.|.|| .:.:|:.| :::|.|:......:...|..
Human   111 RSICERARQGCEALMNKFGFQWPERLRCEHFPRHG-AEQICVGQ-NHSEDGAPALLTTAPPPGLQ 173

  Fly   202 SGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGK 266
            .|:||.       .||.|.||:....:|
Human   174 PGAGGT-------PGGPGGGGAPPRYAT------------------------------------- 194

  Fly   267 EQLLQQQSQMPMMHHPHHWYMNLTV-----QRIAGVPNCGIPCK------GPFFSNDEKDFAGLW 320
                        :.||.|....|.|     .:..|..:|..||:      ..|||.:|..||.||
Human   195 ------------LEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLW 247

  Fly   321 IALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC----- 380
            |..||.||..||..|:||:::|.:||:||||||:|||.||.||:|.|:: .|:..|.:.|
Human   248 ILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIA-GFVLQERVVCNERFS 311

  Fly   381 -DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAA 444
             ||.......|....||::|::.|||.|||||||||||.|||||||:|||:|||..:||||||||
Human   312 EDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAA 376

  Fly   445 WLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRI 509
            |.:|.|:::.:|.:..:|||.:.|:|:||..:.|.|:.||||||||||.|||:||:|||||||||
Human   377 WAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRI 441

  Fly   510 RSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKA 566
            |:::|..     |.|.:|||:||:|||:|||||||||||||.||.||.|:.|.|        .|:
Human   442 RTIMKHD-----GTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKS 501

  Fly   567 LACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            ||.||.....|...|.::|.|:||.|.|.||||||.||||||||.|||:|:.||
Human   502 LAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	64/120 (53%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	180/324 (56%)
		TM helix 1	316..341	CDD:320163	14/24 (58%)
		TM helix 2	350..371	CDD:320163	13/20 (65%)
		TM helix 3	396..422	CDD:320163	18/25 (72%)
		TM helix 4	439..455	CDD:320163	9/15 (60%)
		TM helix 5	477..506	CDD:320163	21/28 (75%)
		TM helix 6	531..558	CDD:320163	22/26 (85%)
		TM helix 7	579..604	CDD:320163	13/24 (54%)
FZD2	NP_001457.1	CRD_FZ2	35..161	CDD:143573	68/150 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..189		9/35 (26%)
		7tmF_FZD2	234..563	CDD:320373	182/328 (55%)
		TM helix 1	243..268	CDD:320373	14/24 (58%)
		TM helix 2	277..298	CDD:320373	13/21 (62%)
		TM helix 3	328..354	CDD:320373	18/25 (72%)
		TM helix 4	371..387	CDD:320373	9/15 (60%)
		TM helix 5	409..438	CDD:320373	21/28 (75%)
		TM helix 6	458..485	CDD:320373	22/26 (85%)
		TM helix 7	514..539	CDD:320373	13/24 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	543..548		3/4 (75%)
		PDZ-binding	563..565